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US 12,590,064 B2Granted
Substituted benzamides for inhibiting perk activity
AssigneeEli Lilly and Company
InventorsMarta Maria Cifuentes-Garcia, Maria Cristina Garcia Paredes
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Abstract
The present application relates, in part, to phenyl-2-hydroxy-acetylamino-2-methylphenyl compounds, such as compounds of Formula I: or pharmaceutically acceptable salts thereof, for inhibiting PERK activity resulting in antitumor activity.
Claims11
A method for inhibiting protein kinase R-like endoplasmic reticulum kinase (PERK) activity in a patient in need thereof, wherein the method comprises administering to the patient an effective amount of a compound of formula I:
- or a pharmaceutically acceptable salt or stereoisomer thereof,
- wherein:
- R is
- R1 is H or F;
- R2 is C1-C3 alkyl;
- and
- X is CH or N.
4 more elements
Dependencies are inferred from the claim text.