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US 12,590,060 B2Granted
Scalable synthetic route for psilocin and psilocybin
AssigneeMindset Pharma Inc.
InventorsAbdelmalik Slassi, Joseph Araujo
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Abstract
The present application relates to cost-effective, practical and scalable synthetic routes for the syntheses for psilocybin (Formula I) and its major metabolite psilocybin (Formula II) and their pharmaceutically acceptable salts. These compounds are useful for the treatment or prevention of mental health disorders, such as major depressive disorder, anxiety and addiction disorders, among others CNS disorders.
Claims24
A process for preparing psilocybin (compound of Formula I),
- the process comprising:
- reacting psilocin (compound of Formula II):
- with (a) di-tert-butylphosphite,
- in the presence of a base or (b) chloro di-tert-butylphosphite,
- to provide a compound of Formula (VI):
- and
- hydrolyzing the compound of Formula VI to provide the psilocybin (compound of Formula I).
4 more elements
Dependencies are inferred from the claim text.