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US 12,590,059 B2Granted
Process for the production of levetiracetam
AssigneeSuzhou Brighthope Pharmatech Co., Ltd.
InventorsSongzhou Hu, Lijun Deng, Wen Yu, Zhen Song
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Abstract
There is disclosed a process for the production of levetiracetam by crystallizing levetiracetam in an aqueous solution, optionally in the presence of a water-soluble solvent. The product of levetiracetam contains no residual organic solvent.
Claims13
A process for the production of (S)-α-ethyl-2-oxo-1-pyrrolidineacetamide of formula (I),
- comprising:
- (a) reacting a (S)-ester of formula (III),
- wherein R is an alkyl group of C1-C8, with an aqueous solution of ammonia or ammonium hydroxide, to form (S)-a-ethyl-2-oxo-1-pyrrolidineacetamide of formula (I);
- (b) crystallizing the (S)-a-ethyl-2-oxo-1-pyrrolidineacetamide of formula (I) of step (a) in the aqueous solution;
- and (c) isolating the (S)-a-ethyl-2-oxo-1-pyrrolidineacetamide of formula (I) of step (b);
- and wherein the(S)-ester of formula (III),
- is prepared by a process comprising the steps of:
- (1) reacting the (S)-acid of formula (II),
- with an excess alcohol of ROH in the presence of a catalyst to form a (S)-ester of formula (III) and (2) removing the excess alcohol to obtain a solution of the (S)-ester of formula (III).
6 more elements
A process for the production of (S)-α-ethyl-2-oxo-1-pyrrolidineacetamide of formula (I),
- comprising:
- (a) dissolving a crude product of (S)-α-ethyl-2-oxo-1-pyrrolidineacetamide of formula (I) in water, and optionally treating the solution with decolorizing charcoal;
- (b) cooling the solution of step (a) to crystallize the (S)-α-ethyl-2-oxo-1-pyrrolidineacetamide of formula (I);
- and
- (c) isolating the (S)-α-ethyl-2-oxo-1-pyrrolidineacetamide of formula (I).
2 more elements
Dependencies are inferred from the claim text.