IGF2BP2 inhibitors and uses thereof

A method of modulating the level of activity of IGF2BP2 in a subject in need thereof, wherein the subject has a high level of IGF2BP2 relative to a normal control, the method comprising administering to the subject in need thereof an effective amount of a compound, wherein the compound has the formula

• wherein
• Ring A is a substituted or unsubstituted cycloalkyl, substituted or unsubstituted heterocycloalkyl, substituted or unsubstituted aryl, or substituted or unsubstituted heteroaryl;
• is a single bond or a double bond;
• R1 is hydrogen, halogen, —CX13, —CHX12, —CH2X1, —OCX13, —OCH2X1, —OCHX12, —CN, —SOn1R1D, —SOv1NR1AR1B, —NHC(O)NR1AR1B, —NR1CNR1AR1B, —ONR1AR1B, —NHC(O)NR1CNR1AR1B, —N(O)m1, —NR1AR1B, —C(O)R1C, —C(O)OR1C, —C(O)NR1AR1B, —OR1D, —NR1ASO2R1D, —NR1AC(O)R1C, —NR1AC(O)OR1C, —NR1AOR1C, —SF5, —N3, substituted or unsubstituted alkyl, substituted or unsubstituted heteroalkyl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted heterocycloalkyl, substituted or unsubstituted aryl, or substituted or unsubstituted heteroaryl;
• R2 is hydrogen, halogen, —CX23, —CHX22, —CH2X2, —OCX23, —OCH2X2, —OCHX22, —CN, —SOn2R2D, —SOv2NR2AR2B, —NHC(O)NR2AR2B, —NR2CNR2AR2B, —ONR2AR2B, —NHC(O)NR2CNR2AR2B, —N(O)m2, —NR2AR2B, —C(O)R2C, —C(O)OR2C, —C(O)NR2AR2B, —OR2D, —NR2ASO2R2D, —NR2AC(O)R2C, —NR2AC(O)OR2C, —NR2AOR2C, —SF5, —N3, substituted or unsubstituted alkyl, substituted or unsubstituted heteroalkyl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted heterocycloalkyl, substituted or unsubstituted aryl, or substituted or unsubstituted heteroaryl;
• R3 is hydrogen, halogen, —CX33, —CHX32, —CH2X3, —OCX33, —OCH2X3, —OCHX32, —CN, —SOn3R3D, —SOv3NR3AR3B, —NHC(O)NR3AR3B, —NR3CNR3AR3B, —ONR3AR3B, —NHC(O)NR3CNR3AR3B, —N(O)m3, —NR3AR3B, —C(O)R3C, —C(O)OR3C, —C(O)NR3AR3B, —OR3D, —NR3ASO2R3D, —NR3AC(O)R3C, —NR3AC(O)OR3C, —NR3AOR3C, —SF5, —N3, substituted or unsubstituted alkyl, substituted or unsubstituted heteroalkyl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted heterocycloalkyl, substituted or unsubstituted aryl, or substituted or unsubstituted heteroaryl;
• R4 is hydrogen, halogen, —CX43, —CHX42, —CH2X4, —OCX43, —OCH2X4, —OCHX42, —CN, —SOn4R4D, —SOv4NR4AR4B, —NHC(O)NR4AR4B, —NR4CNR4AR4B, —ONR4AR4B, —NHC(O)NR4CNR4AR4B, —N(O)m4, —NR4AR4B, —C(O)R4C, —C(O)OR4C, —C(O)NR4AR4B, —OR4D, —NR4ASO2R4D, —NR4AC(O)R4C, —NR4AC(O)OR4C, —NR4AOR4C, —SF5, —N3, substituted or unsubstituted alkyl, substituted or unsubstituted heteroalkyl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted heterocycloalkyl, substituted or unsubstituted aryl, or substituted or unsubstituted heteroaryl;
• R5 is hydrogen, halogen, —CX53, —CHX52, —CH2X5, —OCX53, —OCH2X5, —OCHX52, —CN, —SOn5R5D, —SOv5NR5AR5B, —NHC(O)NR5AR5B, —NR5CNR5AR5B, —ONR5AR5B, —NHC(O)NR5CNR5AR5B, —N(O)m5, —NR5AR5B, —C(O)R5C, —C(O)OR5C, —C(O)NR5AR5B, —OR5D, —NR5ASO2R5D, —NR5AC(O)R5C, —NR5AC(O)OR5C, —NR5AOR5C, —SF5, —N3, substituted or unsubstituted alkyl, substituted or unsubstituted heteroalkyl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted heterocycloalkyl, substituted or unsubstituted aryl, or substituted or unsubstituted heteroaryl;
• R6 is hydrogen, halogen, —CX63, —CHX62, —CH2X6, —OCX63, —OCH2X6, —OCHX62, —CN, —SOn6R6D, —SOv6NR6AR6B, —NHC(O)NR6AR6B, —NR6CNR6AR6B, —ONR6AR6B, —NHC(O)NR6CNR6AR6B, —N(O)m6, —NR6AR6B, —C(O)R6C, —C(O)OR6C, —C(O)NR6AR6B, —OR6D, —NR6ASO2R6D, —NR6AC(O)R6C, —NR6AC(O)OR6C, —NR6AOR6C, —SF5, —N3, substituted or unsubstituted alkyl, substituted or unsubstituted heteroalkyl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted heterocycloalkyl, substituted or unsubstituted aryl, or substituted or unsubstituted heteroaryl;
• R7 is hydrogen, halogen, —CX73, —CHX72, —CH2X7, —OCX73, —OCH2X7, —OCHX72, —CN, —SOn7R7D, —SOv7NR7AR7B, —NHC(O)NR7AR7B, —NR7CN7AR7B, —ONR7AR7B, —NHC(O)NR7CNR7AR7B, —N(O)m7, —NR7AR7B, —C(O)R7C, —C(O)OR7C, —C(O)NR7AR7B, —OR7D, —NR7ASO2R7D, —NR7AC(O)R7C, —NR7AC(O)OR7C, —NR7AOR7C, —SF5, —N3, substituted or unsubstituted alkyl, substituted or unsubstituted heteroalkyl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted heterocycloalkyl, substituted or unsubstituted aryl, or substituted or unsubstituted heteroaryl;
• R8 is hydrogen, halogen, —CX83, —CHX82, —CH2X8, —OCX83, —OCH2X8, —OCHX82, —CN, —SOn8R8D, —SOv8NR8AR8B, —NHC(O)NR8AR8B, —NR8CNR8AR8B, —ONR8AR8B, —NHC(O)NR8CNR8AR8B, —N(O)m8, —NR8AR8B, —C(O)R8C, —C(O)OR8C, —C(O)NR8AR8B, —OR8D, —NR8ASO2R8D, —NR8AC(O)R8C, —NR8AC(O)OR8C, —NR8AOR8C, —SF5, —N3, substituted or unsubstituted alkyl, substituted or unsubstituted heteroalkyl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted heterocycloalkyl, substituted or unsubstituted aryl, or substituted or unsubstituted heteroaryl;
• R9 is hydrogen, halogen, —CX93, —CHX92, —CH2X9, —OCX93, —OCH2X9, —OCHX92, —CN, —SOn9R9D, —SOv9NR9AR9B, —NHC(O)NR9AR9B, —NR9CNR9AR9B, —ONR9AR9B, —NHC(O)NR9CNR9AR9B, —N(O)m9, —NR9AR9B, —C(O)R9C, —C(O)OR9C, —C(O)NR9AR9B, —OR9D, —NR9ASO2R9D, —NR9AC(O)R9C, —NR9AC(O)OR9C, —NR9AOR9C, —SF5, —N3, substituted or unsubstituted alkyl, substituted or unsubstituted heteroalkyl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted heterocycloalkyl, substituted or unsubstituted aryl, or substituted or unsubstituted heteroaryl;
• R10 is hydrogen, halogen, —CX103, —CHX102, —CH2X10, —OCX103, —OCH2X10, —OCHX102, —CN, —SOn10R10D, —SOv10NR10AR10B, —NHC(O)NR10AR10B, —NR10CNR10AR10B, —ONR10AR10B, —NHC(O)NR10CNR10AR10B, —N(O)m10, —NR10AR10B, —C(O)R10C, —C(O)OR10C, —C(O)NR10AR10B, —OR10D, —NR10ASO2R10D, —NR10AC(O)R10C, —NR10AC(O)OR10C, —NR10AOR10C, —SF5, —N3, substituted or unsubstituted alkyl, substituted or unsubstituted heteroalkyl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted heterocycloalkyl, substituted or unsubstituted aryl, or substituted or unsubstituted heteroaryl;
• R11 is hydrogen, halogen, —CX113, —CHX112, —CH2X11, —OCX113, —OCH2X11, —OCHX112, —CN, —SOn11R11D, —SOv11NR11AR11B, —NHC(O)NR11AR11B, —NR11CNR11AR11B, —ONR11AR11B, —NHC(O)NR11CNR11AR11B, —N(O)m11, —NR11AR11B, —C(O)R11C, —C(O)OR11C, —C(O)NR11AR11B, —OR11D, —NR11ASO2R11D, —NR11AC(O)R11C, —NR11AC(O)OR11C, —NR11AOR11C, —SF5, —N3, substituted or unsubstituted alkyl, substituted or unsubstituted heteroalkyl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted heterocycloalkyl, substituted or unsubstituted aryl, or substituted or unsubstituted heteroaryl;
• R12 is hydrogen, halogen, —CX123, —CHX122, —CH2X12, —OCX123, —OCH2X12, —OCHX122, —CN, —SOn12R12D, —SO12NR12AR12B, —NHC(O)NR12AR12B, —NR12CNR12AR12B, —ONR12AR12B, —NHC(O)NR12CNR12AR12B, —N(O)m12, —NR12AR12B, —C(O)R12C, —C(O)OR12C, —C(O)NR12AR12B, —OR12D, —NR12ASO2R12D, —NR12AC(O)R12C, —NR12AC(O)OR12C, —NR12AOR12C, —SF5, —N3, substituted or unsubstituted alkyl, substituted or unsubstituted heteroalkyl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted heterocycloalkyl, substituted or unsubstituted aryl, or substituted or unsubstituted heteroaryl;
• R13 is hydrogen, halogen, —CX133, —CHX132, —CH2X13, —OCX133, —OCH2X13, —OCHX132, —CN, —SOn13R13D, —SOv13NR13AR13B, —NHC(O)NR13AR13B, —NR13CNR13AR13B, —ONR13AR13B, —NHC(O)NR13CNR13AR13B, —N(O)m3, —NR13AR13B, —C(O)R13C, —C(O)OR13C, —C(O)NR13AR13B, —OR13D, —NR13ASO2R13D, —NR13AC(O)R13C, —NR13AC(O)OR13C, —NR13AOR13C, —SF5, —N3, substituted or unsubstituted alkyl, substituted or unsubstituted heteroalkyl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted heterocycloalkyl, substituted or unsubstituted aryl, or substituted or unsubstituted heteroaryl;
• R14 is hydrogen, halogen, —CX143, —CHX142, —CH2X14, —OCX143, —OCH2X14, —OCHX142, —CN, —SOn14R14D, —SOv14NR14AR14B, —NHC(O)NR14AR14B, —NR14CNR14AR14B, —ONR14AR14B, —NHC(O)NR14CNR14AR14B, —N(O)m14, —NR14AR14B, —C(O)R14C, —C(O)OR14C, —C(O)NR14AR14B, —OR14D, —NR14ASO2R14D, —NR14AC(O)R14C, —NR14AC(O)OR14C, —NR14AOR14C, —SF5, —N3, substituted or unsubstituted alkyl, substituted or unsubstituted heteroalkyl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted heterocycloalkyl, substituted or unsubstituted aryl, or substituted or unsubstituted heteroaryl;
• R15 is hydrogen, halogen, —CX153, —CHX152, —CH2X15, —OCX153, —OCH2X15, —OCHX152, —CN, —SOn15R15D, —SOv15NR15AR15B, —NHC(O)NR15AR15B, —NR15CNR15AR15B, —ONR15AR15B, —NHC(O)NR15CNR15AR15B, —N(O)m15, —NR15AR15B, —C(O)R15C, —C(O)OR15C, —C(O)NR15AR15B, —OR15D, —NR15ASO2R15D, —NR15AC(O)R15C, —NR15AC(O)OR15C, —NR15AOR15C, —SF5, —N3, substituted or unsubstituted alkyl, substituted or unsubstituted heteroalkyl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted heterocycloalkyl, substituted or unsubstituted aryl, or substituted or unsubstituted heteroaryl;
• R1 and R2 substituents may be joined to form a substituted or unsubstituted cycloalkyl, substituted or unsubstituted heterocycloalkyl, substituted or unsubstituted aryl, or substituted or unsubstituted heteroaryl;
• R2 and R3 substituents may be joined to form a substituted or unsubstituted cycloalkyl, substituted or unsubstituted heterocycloalkyl, substituted or unsubstituted aryl, or substituted or unsubstituted heteroaryl;
• R3 and R4 substituents may be joined to form a substituted or unsubstituted cycloalkyl, substituted or unsubstituted heterocycloalkyl, substituted or unsubstituted aryl, or substituted or unsubstituted heteroaryl;
• R4 and R5 substituents may be joined to form a substituted or unsubstituted cycloalkyl, substituted or unsubstituted heterocycloalkyl, substituted or unsubstituted aryl, or substituted or unsubstituted heteroaryl;
• R6 and R7 substituents may be joined to form a substituted or unsubstituted cycloalkyl, substituted or unsubstituted heterocycloalkyl, substituted or unsubstituted aryl, or substituted or unsubstituted heteroaryl;
• R7 and R8 substituents may be joined to form a substituted or unsubstituted cycloalkyl, substituted or unsubstituted heterocycloalkyl, substituted or unsubstituted aryl, or substituted or unsubstituted heteroaryl;
• R1 and R9 substituents may be joined to form a substituted or unsubstituted cycloalkyl, substituted or unsubstituted heterocycloalkyl, substituted or unsubstituted aryl, or substituted or unsubstituted heteroaryl;
• R9 and R10 substituents may be joined to form a substituted or unsubstituted cycloalkyl, substituted or unsubstituted heterocycloalkyl, substituted or unsubstituted aryl, or substituted or unsubstituted heteroaryl;
• R11 and R12 substituents may be joined to form a substituted or unsubstituted cycloalkyl, substituted or unsubstituted heterocycloalkyl, substituted or unsubstituted aryl, or substituted or unsubstituted heteroaryl;
• R12 and R13 substituents may be joined to form a substituted or unsubstituted cycloalkyl, substituted or unsubstituted heterocycloalkyl, substituted or unsubstituted aryl, or substituted or unsubstituted heteroaryl;
• R13 and R14 substituents may be joined to form a substituted or unsubstituted cycloalkyl, substituted or unsubstituted heterocycloalkyl, substituted or unsubstituted aryl, or substituted or unsubstituted heteroaryl;
• R14 and R15 substituents may be joined to form a substituted or unsubstituted cycloalkyl, substituted or unsubstituted heterocycloalkyl, substituted or unsubstituted aryl, or substituted or unsubstituted heteroaryl;
• R1A, R1B, R1C, R1D, R2A, R2B, R2C, R2D, R3A, R3B, R3C, R3D, R4A, R4B, R4C, R4D, R5A, R5B, R5C, R5D, R6A, R6B, R6C, R6D, R7A, R7B, R7C, R7D, R8A, R8B, R8C, R8D, R9A, R9B, R9C, R9D, R10A, R10B, R10C, R10D, R11A, R11B, R11C, R11D, R12A, R12B, R12C, R12D, R13A, R13B, R13C, R13D, R14A, R14B, R14C, R14D, R15A, R15B, R15C, and R15D are independently hydrogen, halogen, —CCl3, —CBr3, —CF3, —CI3, —CH2Cl, —CH2Br, —CH2F, —CH2I, —CHCl2, —CHBr2, —CHF2, —CHI2, —CN, —OH, —NH2, —COOH, —CONH2, —NO2, —SH, —SO3H, —SO4H, —SO2NH2, —NHNH2, —ONH2, —NHC(O)NHNH2, —NHC(O)NH2, —NHSO2H, —NHC(O)H, —NHC(O)OH, —NHOH, —OCCl3, —OCBr3, —OCF3, —OCI3, —OCH2Cl, —OCH2Br, —OCH2F, —OCH2I, —OCHCl2, —OCHBr2, —OCHF2, —OCHI2, substituted or unsubstituted alkyl, substituted or unsubstituted heteroalkyl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted heterocycloalkyl, substituted or unsubstituted aryl, or substituted or unsubstituted heteroaryl;
• R1A and R1B substituents bonded to the same nitrogen atom may be joined to form a substituted or unsubstituted heterocycloalkyl or substituted or unsubstituted heteroaryl;
• R2A and R2B substituents bonded to the same nitrogen atom may be joined to form a substituted or unsubstituted heterocycloalkyl or substituted or unsubstituted heteroaryl;
• R3A and R3B substituents bonded to the same nitrogen atom may be joined to form a substituted or unsubstituted heterocycloalkyl or substituted or unsubstituted heteroaryl;
• R4A and R4B substituents bonded to the same nitrogen atom may be joined to form a substituted or unsubstituted heterocycloalkyl or substituted or unsubstituted heteroaryl;
• R5A and R5B substituents bonded to the same nitrogen atom may be joined to form a substituted or unsubstituted heterocycloalkyl or substituted or unsubstituted heteroaryl;
• R6A and R6B substituents bonded to the same nitrogen atom may be joined to form a substituted or unsubstituted heterocycloalkyl or substituted or unsubstituted heteroaryl;
• R7A and R7B substituents bonded to the same nitrogen atom may be joined to form a substituted or unsubstituted heterocycloalkyl or substituted or unsubstituted heteroaryl;
• R8A and R8B substituents bonded to the same nitrogen atom may be joined to form a substituted or unsubstituted heterocycloalkyl or substituted or unsubstituted heteroaryl;
• R9A and R9B substituents bonded to the same nitrogen atom may be joined to form a substituted or unsubstituted heterocycloalkyl or substituted or unsubstituted heteroaryl;
• R10A and R10B substituents bonded to the same nitrogen atom may be joined to form a substituted or unsubstituted heterocycloalkyl or substituted or unsubstituted heteroaryl;
• R11A and R11B substituents bonded to the same nitrogen atom may be joined to form a substituted or unsubstituted heterocycloalkyl or substituted or unsubstituted heteroaryl;
• R12A and R12B substituents bonded to the same nitrogen atom may be joined to form a substituted or unsubstituted heterocycloalkyl or substituted or unsubstituted heteroaryl;
• R13A and R13B substituents bonded to the same nitrogen atom may be joined to form a substituted or unsubstituted heterocycloalkyl or substituted or unsubstituted heteroaryl;
• R14A and R14B substituents bonded to the same nitrogen atom may be joined to form a substituted or unsubstituted heterocycloalkyl or substituted or unsubstituted heteroaryl;
• R15A and R15B substituents bonded to the same nitrogen atom may be joined to form a substituted or unsubstituted heterocycloalkyl or substituted or unsubstituted heteroaryl;
• n1, n2, n3, n4, n5, n6, n7, n8, n9, n10, n11, n12, n13, n14, and n15 are independently an integer from 0 to 4;
• m1, m2, m3, m4, m5, m6, m7, m8, m9, m10, m11, m12, m13, m14, m15, v1, v2, v3, v4, v5, v6, v7, v8, v9, v10, v11, v12, v13, v14, and v15 are independently 1 or 2;
• and
• X1, X2, X3, X4, X5, X6, X7, X8, X9, X10, X11, X12, X13, X14, and X15 are independently —F, —Cl, —Br, or —I.

A method of treating a disease associated with a high level of IGF2BP2 relative to a normal control in a subject in need thereof, said method comprising:

• i) determining the level of IGF2BP2 in the subject in need thereof;
• and
• ii) administering to the subject in need thereof an IGF2BP2 inhibitor, wherein the IGF2BP2 inhibitor decreases IGF2BP2 binding to RNA N6-methyladenosine (m6A);
• wherein the IGF2BP2 inhibitor is a compound having the formula
• wherein
• Ring A is a substituted or unsubstituted cycloalkyl, substituted or unsubstituted heterocycloalkyl, substituted or unsubstituted aryl, or substituted or unsubstituted heteroaryl;
• is a single bond or a double bond;
• R1 is hydrogen, halogen, —CX13, —CHX12, —CH2X1, —OCX13, —OCH2X1, —OCHX12, —CN, —SOn1R1D, —SOv1NR1AR1B, —NHC(O)NR1AR1B, —NR1CNR1AR1B, —ONR1AR1B, —NHC(O)NR1CNR1AR1B, —N(O)m1, —NR1AR1B, —C(O)R1C, —C(O)OR1C, —C(O)NR1AR1B, —OR1D, —NR1ASO2R1D, —NR1AC(O)R1C, —NR1AC(O)OR1C, —NR1AOR1C, —SF5, —N3, substituted or unsubstituted alkyl, substituted or unsubstituted heteroalkyl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted heterocycloalkyl, substituted or unsubstituted aryl, or substituted or unsubstituted heteroaryl;
• R2 is hydrogen, halogen, —CX23, —CHX22, —CH2X2, —OCX23, —OCH2X2, —OCHX22, —CN, —SOn2R2D, —SOv2NR2AR2B, —NHC(O)NR2AR2B, —NR2CNR2AR2B, —ONR2AR2B, —NHC(O)NR2CNR2AR2B, —N(O)m2, —NR2AR2B, —C(O)R2C, —C(O)OR2C, —C(O)NR2AR2B, —OR2D, —NR2ASO2R2D, —NR2AC(O)R2C, —NR2AC(O)OR2C, —NR2AOR2C, —SF5, —N3, substituted or unsubstituted alkyl, substituted or unsubstituted heteroalkyl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted heterocycloalkyl, substituted or unsubstituted aryl, or substituted or unsubstituted heteroaryl;
• R3 is hydrogen, halogen, —CX33, —CHX32, —CH2X3, —OCX33, —OCH2X3, —OCHX32, —CN, —SOn3R3D, —SOv3NR3AR3B, —NHC(O)NR3AR3B, —NR3CNR3AR3B, —ONR3AR3B, —NHC(O)NR3CNR3AR3B, —N(O)m3, —NR3AR3B, —C(O)R3C, —C(O)OR3C, —C(O)NR3AR3B, —OR3D, —NR3ASO2R3D, —NR3AC(O)R3C, —NR3AC(O)OR3C, —NR3AOR3C, —SF5, —N3, substituted or unsubstituted alkyl, substituted or unsubstituted heteroalkyl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted heterocycloalkyl, substituted or unsubstituted aryl, or substituted or unsubstituted heteroaryl;
• R4 is hydrogen, halogen, —CX43, —CHX42, —CH2X4, —OCX43, —OCH2X4, —OCHX42, —CN, —SOn4R4D, —SOv4NR4AR4B, —NHC(O)NR4AR4B, —NR4CNR4AR4B, —ONR4AR4B, —NHC(O)NR4CNR4AR4B, —N(O)m4, —NR4AR4B, —C(O)R4C, —C(O)OR4C, —C(O)NR4AR4B, —OR4D, —NR4ASO2R4D, —NR4AC(O)R4C, —NR4AC(O)OR4C, —NR4AOR4C, —SF5, —N3, substituted or unsubstituted alkyl, substituted or unsubstituted heteroalkyl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted heterocycloalkyl, substituted or unsubstituted aryl, or substituted or unsubstituted heteroaryl;
• R5 is hydrogen, halogen, —CX53, —CHX52, —CH2X5, —OCX53, —OCH2X5, —OCHX52, —CN, —SOn5R5D, —SOv5NR5AR5B, —NHC(O)NR5AR5B, —NR5CNR5AR5B, —ONR5AR5B, —NHC(O)NR5CNR5AR5B, —N(O)m5, —NR5AR5B, —C(O)R5C, —C(O)OR5C, —C(O)NR5AR5B, —OR5D, —NR5ASO2R5D, —NR5AC(O)R5C, —NR5AC(O)OR5C, —NR5AOR5C, —SF5, —N3, substituted or unsubstituted alkyl, substituted or unsubstituted heteroalkyl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted heterocycloalkyl, substituted or unsubstituted aryl, or substituted or unsubstituted heteroaryl;
• R6 is hydrogen, halogen, —CX63, —CHX62, —CH2X6, —OCX63, —OCH2X6, —OCHX62, —CN, —SOn6R6D, —SOv6NR6AR6B, —NHC(O)NR6AR6B, —NR6CNR6AR6B, —ONR6AR6B, —NHC(O)NR6CNR6AR6B, —N(O)m6, —NR6AR6B, —C(O)R6C, —C(O)OR6C, —C(O)NR6AR6B, —OR6D, —NR6ASO2R6D, —NR6AC(O)R6C, —NR6AC(O)OR6C, —NR6AOR6C, —SF5, —N3, substituted or unsubstituted alkyl, substituted or unsubstituted heteroalkyl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted heterocycloalkyl, substituted or unsubstituted aryl, or substituted or unsubstituted heteroaryl;
• R7 is hydrogen, halogen, —CX73, —CHX72, —CH2X7, —OCX73, —OCH2X7, —OCHX72, —CN, —SOn7R7D, —SOv7NR7AR7B, —NHC(O)NR7AR7B, —NR7CNR7AR7B, —ONR7AR7B, —NHC(O)NR7CNR7AR7B, —N(O)m7, —NR7AR7B, —C(O)R7C, —C(O)OR7C, —C(O)NR7AR7B, —OR7D, —NR7ASO2R7D, —NR7AC(O)R7C, —NR7AC(O)OR7C, —NR7AOR7C, —SF5, —N3, substituted or unsubstituted alkyl, substituted or unsubstituted heteroalkyl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted heterocycloalkyl, substituted or unsubstituted aryl, or substituted or unsubstituted heteroaryl;
• R8 is hydrogen, halogen, —CX83, —CHX82, —CH2X8, —OCX83, —OCH2X8, —OCHX82, —CN, —SOn8R8D, —SOv8NR8AR8B, —NHC(O)NR8AR8B, —NR8CNR8AR8B, —ONR8AR8B, —NHC(O)NR8CNR8AR8B, —N(O)m8, —NR8AR8B, —C(O)R8C, —C(O)OR8C, —C(O)NR8AR8B, —OR8D, —NR8ASO2R8D, —NR8AC(O)R8C, —NR8AC(O)OR8C, —NR8AOR8C, —SF5, —N3, substituted or unsubstituted alkyl, substituted or unsubstituted heteroalkyl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted heterocycloalkyl, substituted or unsubstituted aryl, or substituted or unsubstituted heteroaryl;
• R9 is hydrogen, halogen, —CX93, —CHX92, —CH2X9, —OCX93, —OCH2X9, —OCHX92, —CN, —SOn9R9D, —SOv9NR9AR9B, —NHC(O)NR9AR9B, —NR9CNR9AR9B, —ONR9AR9B, —NHC(O)NR9CNR9AR9B, —N(O)m9, —NR9AR9B, —C(O)R9C, —C(O)OR9C, —C(O)NR9AR9B, —OR9D, —NR9ASO2R9D, —NR9AC(O)R9C, —NR9AC(O)OR9C, —NR9AOR9C, —SF5, —N3, substituted or unsubstituted alkyl, substituted or unsubstituted heteroalkyl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted heterocycloalkyl, substituted or unsubstituted aryl, or substituted or unsubstituted heteroaryl;
• R10 is hydrogen, halogen, —CX103, —CHX102, —CH2X10, —OCX103, —OCH2X10, —OCHX102, —CN, —SOn10R10D, —SOv10NR10AR10B, —NHC(O)NR10AR10B, —NR10CNR10AR10B, —ONR10AR10B, —NHC(O)NR10CNR10AR10B, —N(O)m10, —NR1AR10B, —C(O)R10C, —C(O)OR10C, —C(O)NR10AR10B, —OR10D, —NR10ASO2R10D, —NR10AC(O)R10C, —NR10AC(O)OR10C, —NR10AOR10C, —SF5, —N3, substituted or unsubstituted alkyl, substituted or unsubstituted heteroalkyl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted heterocycloalkyl, substituted or unsubstituted aryl, or substituted or unsubstituted heteroaryl;
• R11 is hydrogen, halogen, —CX113, —CHX112, —CH2X11, —OCX113, —OCH2X11, —OCHX112, —CN, —SOn11R11D, —SOv11NR11AR11B, —NHC(O)NR11AR11B, —NR11CNR11AR11B, —ONR11AR11B, —NHC(O)NR11CNR11AR11B, —N(O)m11, —NR11AR11B, —C(O)R11C, —C(O)OR11C, —C(O)NR11AR11B, —OR11D, —NR11ASO2R11D, —NR11AC(O)R11C, —NR11AC(O)OR11C, —NR11AOR11C, —SF5, —N3, substituted or unsubstituted alkyl, substituted or unsubstituted heteroalkyl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted heterocycloalkyl, substituted or unsubstituted aryl, or substituted or unsubstituted heteroaryl;
• R12 is hydrogen, halogen, —CX123, —CHX122, —CH2X12, —OCX123, —OCH2X12, —OCHX122, —CN, —SOn12R12D, —SOv12NR12AR12B, —NHC(O)NR12AR12B, —NR12CNR12AR12B, —ONR12AR12B, —NHC(O)NR12CNR12AR12B, —N(O)m12, —NR12AR12B, —C(O)R12C, —C(O)OR12C, —C(O)NR12AR12B, —OR12D, —NR12ASO2R12D, —NR12AC(O)R12C, —NR12AC(O)OR12C, —NR12AOR12C, —SF5, —N3, substituted or unsubstituted alkyl, substituted or unsubstituted heteroalkyl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted heterocycloalkyl, substituted or unsubstituted aryl, or substituted or unsubstituted heteroaryl;
• R13 is hydrogen, halogen, —CX133, —CHX132, —CH2X13, —OCX133, —OCH2X13, —OCHX132, —CN, —SOn13R13D, —SOv13NR13AR13B, —NHC(O)NR13AR13B, —NR13CNR13AR13B, —ONR13AR13B, —NHC(O)NR13CNR13AR13B, —N(O)m13, —NR13AR13B, —C(O)R13C, —C(O)OR13C, —C(O)NR13AR13B, —OR13D, —NR13ASO2R13D, —NR13AC(O)R13C, —NR13AC(O)OR13C, —NR13AOR13C, —SF5, —N3, substituted or unsubstituted alkyl, substituted or unsubstituted heteroalkyl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted heterocycloalkyl, substituted or unsubstituted aryl, or substituted or unsubstituted heteroaryl;
• R14 is hydrogen, halogen, —CX143, —CHX142, —CH2X14, —OCX143, —OCH2X14, —OCHX142, —CN, —SOn14R14D, —SOv14NR14AR14B, —NHC(O)NR14AR14B, —NR14CNR14AR14B, —ONR14AR14B, —NHC(O)NR14CNR14AR14B, —N(O)m14, —NR14AR14B, —C(O)R14C, —C(O)OR14C, —C(O)NR14AR14B, —OR14D, —NR14ASO2R14D, —NR14AC(O)R14C, —NR14AC(O)OR14C, —NR14AOR14C, —SF5, —N3, substituted or unsubstituted alkyl, substituted or unsubstituted heteroalkyl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted heterocycloalkyl, substituted or unsubstituted aryl, or substituted or unsubstituted heteroaryl;
• R15 is hydrogen, halogen, —CX153, —CHX152, —CH2X15, —OCX153, —OCH2X15, —OCHX152, —CN, —SOn15R15D, —SOv15NR15AR15B, —NHC(O)NR15AR15B, —NR15CNR15AR15B, —ONR15AR15B, —NHC(O)NR15CNR15AR15B, —N(O)m15, —NR15AR15B, —C(O)R15C, —C(O)OR15C, —C(O)NR15AR15B, —OR15D, —NR15ASO2R15D, —NR15AC(O)R15C, —NR15AC(O)OR15C, —NR15AOR15C, —SF5, —N3, substituted or unsubstituted alkyl, substituted or unsubstituted heteroalkyl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted heterocycloalkyl, substituted or unsubstituted aryl, or substituted or unsubstituted heteroaryl;
• R1 and R2 substituents may be joined to form a substituted or unsubstituted cycloalkyl, substituted or unsubstituted heterocycloalkyl, substituted or unsubstituted aryl, or substituted or unsubstituted heteroaryl;
• R2 and R3 substituents may be joined to form a substituted or unsubstituted cycloalkyl, substituted or unsubstituted heterocycloalkyl, substituted or unsubstituted aryl, or substituted or unsubstituted heteroaryl;
• R3 and R4 substituents may be joined to form a substituted or unsubstituted cycloalkyl, substituted or unsubstituted heterocycloalkyl, substituted or unsubstituted aryl, or substituted or unsubstituted heteroaryl;
• R4 and R5 substituents may be joined to form a substituted or unsubstituted cycloalkyl, substituted or unsubstituted heterocycloalkyl, substituted or unsubstituted aryl, or substituted or unsubstituted heteroaryl;
• R6 and R7 substituents may be joined to form a substituted or unsubstituted cycloalkyl, substituted or unsubstituted heterocycloalkyl, substituted or unsubstituted aryl, or substituted or unsubstituted heteroaryl;
• R7 and R8 substituents may be joined to form a substituted or unsubstituted cycloalkyl, substituted or unsubstituted heterocycloalkyl, substituted or unsubstituted aryl, or substituted or unsubstituted heteroaryl;
• R8 and R9 substituents may be joined to form a substituted or unsubstituted cycloalkyl, substituted or unsubstituted heterocycloalkyl, substituted or unsubstituted aryl, or substituted or unsubstituted heteroaryl;
• R9 and R10 substituents may be joined to form a substituted or unsubstituted cycloalkyl, substituted or unsubstituted heterocycloalkyl, substituted or unsubstituted aryl, or substituted or unsubstituted heteroaryl;
• R11 and R12 substituents may be joined to form a substituted or unsubstituted cycloalkyl, substituted or unsubstituted heterocycloalkyl, substituted or unsubstituted aryl, or substituted or unsubstituted heteroaryl;
• R12 and R13 substituents may be joined to form a substituted or unsubstituted cycloalkyl, substituted or unsubstituted heterocycloalkyl, substituted or unsubstituted aryl, or substituted or unsubstituted heteroaryl;
• R13 and R14 substituents may be joined to form a substituted or unsubstituted cycloalkyl, substituted or unsubstituted heterocycloalkyl, substituted or unsubstituted aryl, or substituted or unsubstituted heteroaryl;
• R14 and R15 substituents may be joined to form a substituted or unsubstituted cycloalkyl, substituted or unsubstituted heterocycloalkyl, substituted or unsubstituted aryl, or substituted or unsubstituted heteroaryl;
• R1A, R1B, R1C, R1D, R2A, R2B, R2C, R2D, R3A, R3B, R3C, R3D, R4A, R4B, R4C, R4D, R5A, R5B, R5C, R5D, R6A, R6B, R6C, R6D, R7A, R7B, R7C, R7D, R8A, R8B, R8C, R8D, R9A, R9B, R9C, R9D, R10A, R10B, R10C, R10D, R11A, R11B, R11C, R11D, R12A, R12B, R12C, R12D, R13A, R13B, R13C, R13D, R14A, R14B, R14C, R14D, R15A, R15B, R15C, and R15D are independently hydrogen, halogen, —CCl3, —CBr3, —CF3, —CI3, —CH2Cl, —CH2Br, —CH2F, —CH2I, —CHCl2, —CHBr2, —CHF2, —CHI2, —CN, —OH, —NH2, —COOH, —CONH2, —NO2, —SH, —SO3H, —SO4H, —SO2NH2, —NHNH2, —ONH2, —NHC(O)NHNH2, —NHC(O)NH2, —NHSO2H, —NHC(O)H, —NHC(O)OH, —NHOH, —OCCl3, —OCBr3, —OCF3, —OCI3, —OCH2Cl, —OCH2Br, —OCH2F, —OCH2I, —OCHCl2, —OCHBr2, —OCHF2, —OCHI2, substituted or unsubstituted alkyl, substituted or unsubstituted heteroalkyl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted heterocycloalkyl, substituted or unsubstituted aryl, or substituted or unsubstituted heteroaryl;
• R1A and R1B substituents bonded to the same nitrogen atom may be joined to form a substituted or unsubstituted heterocycloalkyl or substituted or unsubstituted heteroaryl;
• R2A and R2B substituents bonded to the same nitrogen atom may be joined to form a substituted or unsubstituted heterocycloalkyl or substituted or unsubstituted heteroaryl;
• R3A and R3B substituents bonded to the same nitrogen atom may be joined to form a substituted or unsubstituted heterocycloalkyl or substituted or unsubstituted heteroaryl;
• R4A and R4B substituents bonded to the same nitrogen atom may be joined to form a substituted or unsubstituted heterocycloalkyl or substituted or unsubstituted heteroaryl;
• R5A and R5B substituents bonded to the same nitrogen atom may be joined to form a substituted or unsubstituted heterocycloalkyl or substituted or unsubstituted heteroaryl;
• R6A and R6B substituents bonded to the same nitrogen atom may be joined to form a substituted or unsubstituted heterocycloalkyl or substituted or unsubstituted heteroaryl;
• R7A and R7B B substituents bonded to the same nitrogen atom may be joined to form a substituted or unsubstituted heterocycloalkyl or substituted or unsubstituted heteroaryl;
• R8A and R8B substituents bonded to the same nitrogen atom may be joined to form a substituted or unsubstituted heterocycloalkyl or substituted or unsubstituted heteroaryl;
• R9A and R9B substituents bonded to the same nitrogen atom may be joined to form a substituted or unsubstituted heterocycloalkyl or substituted or unsubstituted heteroaryl;
• R10A and R11B substituents bonded to the same nitrogen atom may be joined to form a substituted or unsubstituted heterocycloalkyl or substituted or unsubstituted heteroaryl;
• R11A and R11B substituents bonded to the same nitrogen atom may be joined to form a substituted or unsubstituted heterocycloalkyl or substituted or unsubstituted heteroaryl;
• R12A and R12B substituents bonded to the same nitrogen atom may be joined to form a substituted or unsubstituted heterocycloalkyl or substituted or unsubstituted heteroaryl;
• R13A and R13B substituents bonded to the same nitrogen atom may be joined to form a substituted or unsubstituted heterocycloalkyl or substituted or unsubstituted heteroaryl;
• R14A and R14B substituents bonded to the same nitrogen atom may be joined to form a substituted or unsubstituted heterocycloalkyl or substituted or unsubstituted heteroaryl;
• R15A and R15B substituents bonded to the same nitrogen atom may be joined to form a substituted or unsubstituted heterocycloalkyl or substituted or unsubstituted heteroaryl;
• n1, n2, n3, n4, n5, n6, n7, n8, n9, n10, n11, n12, n13, n14, and n15 are independently an integer from 0 to 4;
• m1, m2, m3, m4, m5, m6, m7, m8, m9, m10, m11, m12, m13, m14, m15, v1, v2, v3, v4, v5, v6, v7, v8, v9, v10, v11, v12, v13, v14, and v15 are independently 1 or 2;
• and
• X1, X2, X3, X4, X5, X6, X7, X8, X9, X10, X11, X12, X3, X14, and X15 are independently —F, —Cl, —Br, or —I.