Method for making multiparticulates from a liquid feed employing a spinning disc sprayer

A method of making multiparticulates, comprising:

• providing a molten feed comprising an active ingredient and an excipient;
• providing a spinning disc sprayer comprising:
• a rotatable disc having a feed-receiving surface and an axis of rotation, the feed-receiving surface defining a well centered on the axis of rotation;
• and
• a hollow drive shaft having a longitudinal shaft lumen and an axis of rotation attached to the rotatable disc;
• directing the molten feed through the lumen onto the feed-receiving surface, and atomizing the molten feed from the rotatable disc to form solid multiparticulates;
• wherein the axes of rotation of the hollow drive shaft and rotatable disc are coaxial, a downward end of the hollow drive shaft is disposed with a distributor for regulating flow of the molten feed into the well, and the distributor and the well are together configured for providing a substantially radial, uniform outward flow of the molten feed across the feed-receiving surface,
• wherein the number of rotatable discs is one and the number of feed-receiving surfaces is one, and
• wherein the distributor comprises a plurality of apertures disposed around a circumference of the downward end of the hollow drive shaft for an outflow of the molten feed.