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US 12,589,330 B2Granted
Modified column for expanded bed adsorption and methods of use thereof
AssigneeEvolve Biologics Inc.
InventorsDavid Miller, Gillian Vanderlee, Hrvoje Beg, Aryn Holness
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Abstract
The present disclosure provides chromatography columns and methods of chromatographic separation using the same. In particular, the disclosure provides modified columns where the cross-sectional area of the column increases in an area near the end of the column in a flared manner. The modified columns can be used in Expanded Bed Absorption (EBA) systems.
Claims11
A chromatography column comprising:
- a tubular housing for containing a chromatographic media, the tubular housing comprising a vertical main shaft, a lower end and an upper outwardly flared region, the lower end and the upper outwardly flared region separated by the vertical main shaft, wherein the upper outwardly flared region has a bottom end and a top end, the top end having a diameter larger than a diameter of the bottom end;
- an inlet for providing a fluid to the lower end;
- and
- an outlet for collecting eluted material, wherein the outlet extends from the upper outwardly flared region,
- wherein the vertical main shaft has a height of 10 to 100 centimeters and a diameter of 2 to 50 centimeters and the upper outwardly flared region extends from the vertical main shaft at an angle of 20 to 45 degrees from the vertical main shaft.
2 more elements
Dependencies are inferred from the claim text.