Artificial pancreas integrated CGM architectures and designs

A system for managing a patient's glucose levels, the system comprising:

• a glucose sensor configured to generate data signals corresponding to the patient's glucose levels;
• an insulin pump;
• sensor electronics comprising a memory storing a predetermined glucose measurement uncertainty, and a processor operatively coupled to the glucose sensor and configured to determine glucose levels based on the generated data signals and a lag correction, and to output the glucose levels and the predetermined glucose measurement uncertainty;
• and
• a computing device in communication with the sensor electronics, the computing device comprising a processor configured to (i) receive the outputted glucose levels from the sensor electronics, (ii) receive the predetermined glucose measurement uncertainty in the outputted glucose levels, (iii) execute a closed-loop algorithm, including adjusting an amount of weight placed on the outputted glucose levels using the predetermined glucose measurement uncertainty, and (iv) provide insulin delivery instructions to the insulin pump using an output from the closed-loop algorithm.