Cyclic aspiration system producing cyclic aspiration pressure waveform using vacuum pump and positive pressure pulse generator mechanism

A method of using a cyclic aspiration system to produce a cyclic aspiration pressure waveform of intermittent cyclic intervals of vacuum pressure below atmospheric pressure and a positive pressure higher than the vacuum pressure;

• wherein the cyclic aspiration system includes:
• a vacuum pump generating the vacuum pressure;
• a positive pressure pulse generator mechanism connected in fluid communication with the vacuum pump;
• the positive pressure pulse generator mechanism including at least one displaceable member displaceable within a housing, wherein the at least one displaceable member controls passage therethrough the housing of the vacuum pressure and produces the positive pressure pulse by compressing collectable fluid therein;
• an aspiration catheter connected in fluid communication with the positive pressure pulse generator mechanism;
• and at least one actuator arranged externally of the housing displacing the at least one displaceable member within the housing;
• wherein the method comprises:
• delivering the aspiration catheter through a vessel to a target site on a proximal side of a clot;
• applying the vacuum pressure generated by the vacuum pump;
• and
• producing the cyclic aspiration pressure waveform by moving the at least one displaceable member via the at least one actuator to control passage therethrough the housing of the vacuum pressure while also intermittently cyclically producing the positive pressure pulse by compressing collectable fluid therein;
• wherein the at least one displaceable member includes a first displaceable member and a second displaceable member, each independently displaceable in the housing;
• wherein the first displaceable member is configured to control passage therethrough the housing of the vacuum pressure and the second displaceable member is configured to produce the positive pressure pulse by compressing the collectable fluid therein.

A cyclic aspiration system producing a cyclic aspiration pressure waveform of intermittent cyclic intervals of vacuum pressure below atmospheric pressure and a positive pressure higher than the vacuum pressure, the system comprising:

• a vacuum pump generating the vacuum pressure;
• a positive pressure pulse generator mechanism connected in fluid communication with the vacuum pump;
• the positive pressure pulse generator mechanism including at least one displaceable member displaceable within a housing, wherein the at least one displaceable member controls passage therethrough the housing of the vacuum pressure and produces the positive pressure pulse by compressing collectable fluid therein;
• an aspiration catheter connected in fluid communication with the positive pressure pulse generator mechanism;
• and
• at least one actuator arranged externally of the housing displacing the at least one displaceable member within the housing;
• wherein the at least one displaceable member is a flexible diaphragm and ball valve secured thereto projecting into an internal cavity of the housing.

A cyclic aspiration system producing a cyclic aspiration pressure waveform of intermittent cyclic intervals of vacuum pressure below atmospheric pressure and a positive pressure higher than the vacuum pressure, the system comprising:

• a vacuum pump generating the vacuum pressure;
• a positive pressure pulse generator mechanism connected in fluid communication with the vacuum pump;
• the positive pressure pulse generator mechanism including at least one displaceable member displaceable within a housing, wherein the at least one displaceable member controls passage therethrough the housing of the vacuum pressure and produces the positive pressure pulse by compressing collectable fluid therein;
• an aspiration catheter connected in fluid communication with the positive pressure pulse generator mechanism;
• at least one actuator arranged externally of the housing displacing the at least one displaceable member within the housing;
• and
• a positive pressure pulse amplitude adjustment mechanism varying a maximum return travel of the at least one displaceable member within the housing.

A method of using a cyclic aspiration system to produce a cyclic aspiration pressure waveform of intermittent cyclic intervals of vacuum pressure below atmospheric pressure and a positive pressure higher than the vacuum pressure;

• wherein the cyclic aspiration system includes:
• a vacuum pump generating the vacuum pressure;
• a positive pressure pulse generator mechanism connected in fluid communication with the vacuum pump;
• the positive pressure pulse generator mechanism including at least one displaceable member displaceable within a housing, wherein the at least one displaceable member controls passage therethrough the housing of the vacuum pressure and produces the positive pressure pulse by compressing collectable fluid therein;
• an aspiration catheter connected in fluid communication with the positive pressure pulse generator mechanism;
• and at least one actuator arranged externally of the housing displacing the at least one displaceable member within the housing;
• wherein the at least one displaceable member is a flexible diaphragm and ball valve secured thereto projecting into an internal cavity of the housing;
• wherein
• the method comprises:
• delivering the aspiration catheter through a vessel to a target site on a proximal side of a clot;
• applying the vacuum pressure generated by the vacuum pump;
• and
• producing the cyclic aspiration pressure waveform by moving the at least one displaceable member via the at least one actuator to control passage therethrough the housing of the vacuum pressure while also intermittently cyclically producing the positive pressure pulse by compressing collectable fluid therein.

A method of using a cyclic aspiration system to produce a cyclic aspiration pressure waveform of intermittent cyclic intervals of vacuum pressure below atmospheric pressure and a positive pressure higher than the vacuum pressure;

• wherein the cyclic aspiration system includes:
• a vacuum pump generating the vacuum pressure;
• a positive pressure pulse generator mechanism connected in fluid communication with the vacuum pump;
• the positive pressure pulse generator mechanism including at least one displaceable member displaceable within a housing, wherein the at least one displaceable member controls passage therethrough the housing of the vacuum pressure and produces the positive pressure pulse by compressing collectable fluid therein;
• an aspiration catheter connected in fluid communication with the positive pressure pulse generator mechanism;
• at least one actuator arranged externally of the housing displacing the at least one displaceable member within the housing;
• and a positive pressure pulse amplitude adjustment mechanism varying a maximum return travel of the at least one displaceable member within the housing;
• wherein the method comprises:
• delivering the aspiration catheter through a vessel to a target site on a proximal side of a clot;
• applying the vacuum pressure generated by the vacuum pump;
• and
• producing the cyclic aspiration pressure waveform by moving the at least one displaceable member via the at least one actuator to control passage therethrough the housing of the vacuum pressure while also intermittently cyclically producing the positive pressure pulse by compressing collectable fluid therein.