Hydrogels for in situ-forming tissue constructs
AssigneesThe Board of Trustees of the Leland Stanford Junior University, The United States Government as represented by the Departement of Veterans Affairs
InventorsDavid Myung, Fang Chen, Gabriella Fernandes-Cunha, Sarah Hull, Sarah Heilshorn, Christopher Lindsay, Christopher Madl, Hyun Jong Lee
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Abstract
Compositions and methods are provided for lamellar and defect reconstruction of corneal stromal tissue using biomaterials that form a defined hydrogel structure in situ, including interpenetrating (IPN) and semi-IPN hydrogels.
Claims19
A composition for use as an in-situ-forming hydrogel in treating or reconstructing a surgically incised or wounded area in a mammalian subject in need thereof, comprising an interpenetrating polymer network (IPN) or semi-IPN of independently associated, wherein the hydrogel is an IPN comprising a first polymer that is functionalized with first reactive groups, and a second polymer that is functionalized with second reactive groups, wherein each of the polymer components is cross-linked with a different modality so that independent networks are formed;
- wherein upon mixing of the first and second polymers the first polymer and the second polymer form an interpenetrating polymer network on the wounded area in situ without the need for an external energy source.
A composition for use as an in-situ-forming hydrogel in treating or reconstructing a surgically incised or wounded area in a mammalian subject in need thereof, comprising an interpenetrating polymer network (IPN) or semi-IPN of independently associated, wherein the hydrogel is a semi IPN comprising a first polymer that is functionalized with first reactive groups, and a second polymer that is not chemically cross-linked;
- wherein upon mixing of the first and second polymers the first polymer and the second polymer form an interpenetrating polymer network on the wounded area in situ without the need for an external energy source.
A composition for use as an in-situ-forming hydrogel in treating or reconstructing a surgically incised or wounded area in a mammalian subject in need thereof, comprised of a network of polymer crosslinked with multi-arm PEG;
- comprising:
- a peptide sequence comprising primary amine groups, and a multi-arm PEG crosslinker that is functionalized with reactive groups;
- wherein
- upon mixing the peptide sequence forms a hydrogel without the need for an external energy source.
Dependencies are inferred from the claim text.