Occlusive implant compositions
AssigneeUniversity of Virginia Patent Foundation
InventorsJohn C. Herr, Alexander L. Klibanov, Kevin Simon Eisenfrats
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Abstract
Disclosed are methods of delivering an agent to the lumen of the vas deferens under guidance of ultrasound imaging. The methods include vas-occlusive contraception in which the vas deferens is non-surgically isolated and an occlusive substance is percutaneously administered into the lumen of the vas deferens under ultrasound. Also disclosed are methods of reversal of vas-occlusive contraception and methods of delivering an agent to the lumen of the vas deferens. Also disclosed are compositions for use in the methods of the invention.
Claims15
A composition comprising:
- one or more species comprising poly(ethylene glycol) (PEG) in a solvent and capable of crosslinking to form a crosslinked network;
- wherein the one or more species and/or the crosslinked network are capable of being injected into a vas deferens;
- wherein the one or more species are present in the solvent at a concentration ranging from about 0.15 g/mL to about 0.5 g/mL;
- and
- wherein the crosslinked network is capable of inducing azoospermia or severe oligospermia in vivo.
A pre-filled syringe comprising:
- a composition comprising:
- one or more species comprising poly(ethylene glycol) (PEG) in a solvent and capable of crosslinking to form a crosslinked network;
- wherein the one or more species and/or the crosslinked network are capable of being injected into a vas deferens;
- wherein the one or more species are present in the solvent at a concentration ranging from about 0.15 g/mL to about 0.5 g/mL and
- wherein the crosslinked network is capable of inducing azoospermia or severe oligospermia in vivo.
Dependencies are inferred from the claim text.