Compositions and methods for treating wounds
AssigneeRutgers, The State University of New Jersey
InventorsMaricely Ramirez Hernandez, Tewodros Asefa, Jeffrey Boyd, Javiera Norambuena-Morales
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Abstract
The present disclosure relates to compositions and methods of treating a wound, or location of interest, in a subject by topically administering to the subject the therapeutic composition of the disclosure. The composition of the disclosure comprises nanoparticle (NP) composites for delivering one or more therapeutic agents to the wound.
Claims19
A nanoparticle (NP) functionalized with at least one pH-responsive moiety, wherein at least one cargo is associated with the nanoparticle or the at least one pH-responsive moiety, and wherein swelling of the at least one pH-responsive moiety allows for release of the at least one cargo from the NP or the pH-responsive moiety comprising the cargo,
- wherein the nanoparticle comprises a silica nanoparticle (SNP) or a titania nanoparticle (TNP), wherein the nanoparticle is:
- (a) a porous nanoparticle comprising a plurality of pores, which allow for loading of the cargo in the plurality of pores, or
- (b) a non-porous nanoparticle;
- wherein the pH-responsive moiety is selected from the group consisting of N-(2-aminoethyl)-3-aminopropyltrimethoxysilane (DAMO) and a polymer or copolymer selected from the group consisting of polyethyleneimine (PEI), poly(N-isopropylacrylamide), poly(acrylic acid), poly(lactide-co-glycolide) (PLGA), polyethylene glycol, and polyoxazoline, PAMAM dendrimers;
- and
- wherein the cargo comprises at least one selected from the group consisting of a therapeutic cargo, a molecular marker, and a biomarker.
A composition comprising about 0.10% to about 0.25% of chitosan, about 0.10% to about 2.0% of sodium alginate, about 0.1% to about 0.5% of gelatin, about 0.01% to about 1% of grapeseed oil, and Poly-vinyl-alcohol (PVA), and aloe vera gel,
- wherein the composition is formulated for application to a wound for promoting healing of the wound,
- wherein the composition further comprises a nanoparticle (NP) functionalized with at least one pH-responsive moiety, wherein at least one cargo is associated with the nanoparticle or the at least one pH-responsive moiety, and wherein swelling of the at least one pH-responsive moiety allows for release of the at least one cargo from the NP or the pH-responsive moiety comprising the cargo,
- wherein the nanoparticle comprises a silica nanoparticle (SNP) or a titania nanoparticle (TNP), wherein the nanoparticle is:
- (a) a porous nanoparticle comprising a plurality of pores, which allow for loading of the cargo in the plurality of pores, or
- (b) a non-porous nanoparticle;
- wherein the pH-responsive moiety is selected from the group consisting of N-(2-aminoethyl)-3-aminopropyltrimethoxysilane (DAMO) and a polymer or copolymer;
- and
- wherein the cargo comprises at least one selected from the group consisting of a therapeutic cargo, a molecular marker, or a biomarker.
Dependencies are inferred from the claim text.