GLP-1/GIP dual agonist, preparation method and use thereof

A compound selected from the group consisting of:

• the compound of SEQ ID NO:5, in which K at position 24 is chemically modified through conjugation to the ε-amino of the K side-chain with ([2-(2-amino-ethoxy)-ethoxy]-acetyl)2-(γ-Glu)1-CO—(CH2)20—CO2H;
• and the C-terminal amino acid is amidated as a C-terminal primary amide;
• and
• the compound of SEQ ID NO:7, in which the K at position 24 is chemically modified through conjugation to the ε-amino of the K side-chain with ([2-(2-amino-ethoxy)-ethoxy]-acetyl)3-(γ-Glu)1-CO—(CH2)20—CO2H;
• and the C-terminal amino acid is amidated as a C-terminal primary amide.