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US 12,589,149 B2Granted
Method of modulating mucosal immunogenicity
AssigneeAdvagene Biopharma Co., Ltd.
InventorsYu-Shen Hsu, Mingi Chang, Ssu-Wei Kang
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Abstract
The present disclosure provides a novel method for modulating mucosal immune response, comprising administering an antigen to a mucosal site of a subject in need thereof, and administering an immunomodulator to a different anatomical mucosal site of said subject. The antigen may be administered to sublingual mucosa and the immunomodulator may be administered to intranasal mucosa. An immune response involving production of IgG and IgA against the antigen may be elicited.
Claims18
A method of modulating a mucosal immune response, comprising:
- administering an antigen to a sublingual mucosa or an oral mucosa of a subject in need thereof;
- and
- administering an immunomodulator to an intranasal mucosa of said subject,
- wherein the antigen is an immunogen, and the immunomodulator is detoxified Escherichia coli heat-labile toxin (LTh (αK)).
1 more element
Dependencies are inferred from the claim text.