Multivalent HVT vector vaccine
AssigneeIntervet Inc.
InventorsMartijn Alexander Langereis, Iwan Verstegen
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Abstract
The present invention describes a recombinant herpesvirus of turkeys (rHVT) that can be used as a vector vaccine for poultry against infection and disease from multiple poultry pathogens. Specifically the rHVT expresses an infectious bursal disease virus (IBDV) viral protein 2 (VP2) gene and a Newcastle disease virus (NDV) fusion (F) protein gene from a first and a second expression cassette inserted in the unique small (Us) region, and expresses an avian influenza vims (AIV) haemagglutinin (HA) gene from a third expression cassette inserted in the unique long (UL) region of the genome of said rHVT either between the UL40 and UL41 genes, or between the UL44 and UL45 genes. This rHVT can be used to vaccinate poultry against MDV, IBDV, NDV and AIV.
Claims20
A recombinant herpesvirus of turkeys (rHVT) expressing an infectious bursal disease virus (IBDV) viral protein 2 (VP2) gene and a Newcastle disease virus (NDV) fusion (F) protein gene from a first and a second expression cassette which are inserted in the unique small (Us) region of the genome of said rHVT, wherein the rHVT also expresses an avian influenza virus (AIV) haemagglutinin (HA) gene from a third expression cassette which is inserted in the unique long (UL) region of the genome of said rHVT either between the UL40 and UL41 genes, or between the UL44 and UL45 genes.
Dependencies are inferred from the claim text.