DNA vaccine capable of effectively treating and/or preventing type 1 diabetes and use thereof
AssigneeThe Fifth Medical Center of Chinese PLA General Hospital
InventorsYongzhi Xi, Song Yun
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Abstract
Provided is use of a recombinant nucleic acid construct containing a B7-2-PE40 exotoxin fusion gene in the preparation of a DNA vaccine or medicament for treatment and/or prevention of type 1 diabetes. The DNA vaccine can reduce blood glucose in patient with type 1 diabetes, restore the secretion of insulin of the patients per se, and reduce the contents of islet cell autoantibody (ICA) and glutamate decarboxylase autoantibody (GAD) in the patients.
Claims10
A method for treating type 1 diabetes in a subject, the method comprising administering to the subject suffering the type 1 diabetes an effective amount of (a) a recombinant nucleic acid construct comprising a B7-2-PE40 (Pseudomonas exotoxin A 40 kD) exotoxin fusion gene, wherein the B7-2-PE40 exotoxin fusion gene has the sequence as shown in SEQ ID NO:1;
- or (b) therapeutic DNA vaccine or a pharmaceutical composition comprising said recombinant nucleic acid construct.
Dependencies are inferred from the claim text.