Treatment of cachexia using fibroblast cells and products thereof
AssigneeFibrobiologics, Inc.
InventorsPete O'Heeron, Thomas Ichim
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Abstract
Disclosed are methods and compositions related to treatment, amelioration or prevention of cachexia or inflammation related to cachexia in a subject. As disclosed, cachexia or inflammation related to cachexia can be treated, ameliorated or prevented by the administration of an effective amount of a composition including immune-modulating fibroblasts to the subject.
Claims12
A method for ameliorating cachexia, or inflammation related thereto, in an individual, comprising administering an effective amount of immune-modulating fibroblasts to the individual;
- wherein the fibroblasts express detectable levels of one or more markers selected from the group consisting of SSEA3, SSEA4, Tra-1-60, Tra-1-81, Tra-2-54, Oct-4, CD13, CD44, CD49b, CD105, aminopeptidase N, and a combination thereof;
- and administered in the form of a single cell suspension.
A method of increasing the weight of an individual with cachexia or at risk of having cachexia, comprising the step of administering an effective amount of fibroblasts to the individual;
- wherein the fibroblasts express detectable levels of one or more markers selected from the group consisting of SSEA3, SSEA4, Tra-1-60, Tra-1-81, Tra-2-54, Oct-4, CD13, CD44, CD49b, CD105, aminopeptidase N, and a combination thereof;, and administered in the form of a single cell suspension.
Dependencies are inferred from the claim text.