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US 12,589,112 B2Granted
Oncolytic virus compositions including IL-15 complex and methods for the treatment of cancer
AssigneeCity of Hope
InventorsJianhua Yu, Michael A. Caligiuri
Life of this patent
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Abstract
Provided herein, inter alia, are compositions and methods including recombinant oncolytic viruses expressing human IL-15 and human IL-15Rα-sushi domain for the treatment of cancer and immune disorders. The recombinant oncolytic viruses may be used in combination with immune cells expressing chimeric antigen receptors (CAR) targeting EGFR and EGFR mutants.
Claims20
A recombinant oncolytic herpes simplex virus (HSV) comprising:
- an expression cassette comprising a nucleic acid encoding a human IL-15 domain and a nucleic acid encoding a human IL-15Rα sushi domain, wherein the nucleic acid encoding the human IL-15Rα sushi domain comprises SEQ ID NO:2.
A recombinant oncolytic herpes simplex virus (HSV) comprising:
- an expression cassette encoding a human IL15 domain and a human IL-15Rα sushi domain, wherein the expression cassette comprises SEQ ID NO:3.
Dependencies are inferred from the claim text.