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US 12,589,109 B2Granted
Therapy to stimulate hippocampal neural progenitors and adult neurogenesis
AssigneeUniversity of Notre Dame du Lac
InventorsKasturi Haldar, Md. Suhail Alam, Arpitha Mysore Rajashekara
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Abstract
Aspects of the invention are directed to methods of stimulating or promoting neurogenesis by administering to a subject of a composition comprising a cyclodextrin and a polyethylene glycol to alleviate learning, memory and cognitive deficits present in subjects afflicted with various brain disorders or from neurodegenerative disorder associated with aging.
Claims17
A method for treating Kabuki Syndrome in a subject suffering therefrom comprising:
- administering to the subject a therapeutically effective amount of a composition comprising a cyclodextrin present in an amount of about 13% to about 45% w/w and a polyethylene glycol (PEG) present in an amount of greater than 8% w/w, thereby treating the Kabuki Syndrome.
A method for treating Kabuki Syndrome in a subject consisting of:
- administering intrathecally to the central nervous system of a subject a therapeutically effective amount of a composition consisting essentially of a cyclodextrin present in an amount of about 13% to about 45% w/w and a polyethylene glycol (PEG) present in an amount greater than 8% w/w, thereby treating the Kabuki Syndrome in the subject.
A composition consisting of:
- i) about 25% to about 45% w/w cyclodextrin;
- and
- ii) about 20% to about 45% w/w polyethylene glycol (PEG).
Dependencies are inferred from the claim text.