Antimicrobial and antiviral effects of C2-C7 alkyl boronic acids
AssigneesCornell University, The Board of Trustees of the Leland Stanford Junior University
InventorsKenneth W. Simpson, Shiying Zhang, Michael Fischbach
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Abstract
The present application relates to methods for treatment of bacteria and viruses with C2-C7 alkyl boronic acids to reduce growth and virulence.
Claims28
A method of selectively suppressing bacterial growth, said method comprising:
- providing a C2-C7 alkyl boronic acid and
- administering the C2-C7 alkyl boronic acid to bacteria to suppress growth of the bacteria, wherein said administering the C2-C7 alkyl boronic acid achieves bacterial taming by having high activity against enteric pathogens and low activity against probiotic and non-enteropathogenic Gram Positive bacteria.
A method of altering bacterial virulence, said method comprising:
- providing a C2-C7 alkyl boronic acid and
- administering the C2-C7 alkyl boronic acid to bacteria to alter virulence of the bacteria, wherein said administering the C2-C7 alkyl boronic acid achieves bacterial taming by having high activity against enteric pathogens and low activity against probiotic and non-enteropathogenic Gram Positive bacteria.
A method of treating a diarrheal disease, an intestinal inflammatory condition, or an intestinal cancer in a subject, said method comprising:
- selecting a subject with a diarrheal disease, an intestinal inflammatory condition, or an intestinal cancer and
- administering a C2-C7 alkyl boronic acid to the subject to treat the diarrheal disease, the intestinal inflammatory condition, or the intestinal cancer.
A method of reducing viral virulence, said method comprising:
- providing a C2-C7 alkyl boronic acid and
- administering the C2-C7 alkyl boronic acid to viruses to reduce virulence of the viruses.
A method of treating a viral infection, said method comprising:
- selecting a subject with a viral infection and
- administering a C2-C7 alkyl boronic acid to the subject to treat the viral infection.
Dependencies are inferred from the claim text.