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US 12,589,102 B2Granted
Injectable sustained-release formulations for treatment of joint pain and inflammation
AssigneeFORDOZ Pharma Corp.
InventorsSydney Ugwu, James He, Zengli Fu
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Abstract
Drug-loaded microspheres containing both a steroidal anti-inflammatory drug and a non-steroidal anti-inflammatory drug and injectable formulations containing the microspheres for sustained release of both drugs are disclosed. Methods of making such drug-loaded microspheres, formulations, and use of them for treating pains and inflammations, especially those caused by rheumatoid arthritis or osteoarthritis using such microspheres and formulations are also described.
Claims9
An injectable sustained-release formulation, comprising:
- (a) drug microspheres comprising both methylprednisolone acetate (MPA) and celecoxib (CXB) encapsulated in poly(lactic-co-glycolic acid) copolymers (PLGA) with a molecular weight in the range between 10 kD and 130 kD and a molar ratio of lactic acid:glycolic acid between about 50:50 to about 75:25,
- (b) a diluent solution in which the drug microspheres are suspended
- wherein the MPA comprises between 15% and 40% by weight of the drug microspheres and the CXB comprises between 15% to 40% by weight of the drug microspheres;
- the drug microspheres have a mean diameter of between 40 μm and 70 μm;
- and
- the drug microspheres release at least 30% of the MPA in the first week following parenteral administration to a patient and the remaining MPA is released over at least one month following the parenteral administration to the patient.
3 more elements
Dependencies are inferred from the claim text.