Polycyclic compound acting as kinase inhibitor

A compound of formula (I), or optical isomers, pharmaceutically acceptable salts, prodrugs, deuterated forms, hydrates, or solvates thereof:

• wherein:
• “*” indicates a chiral center;
• X is hydrogen, deuterium, halogen, C1-4 alkyl, OR1, NR1R2, or N(R1)C(O)R3;
• each R is independently hydrogen or C1-4 alkyl;
• or when two R are simultaneously attached to one carbon atom, the two R and the carbon atom to which they are attached optionally form a carbonyl group (C═O);
• G is NRf, O, S, S(O), S(O)2 or CRgRg;
• p is 0, 1, 2 or 3;
• m and n are each independently 0, 1, 2 or 3;
• with the proviso that m and n cannot simultaneously be 0;
• R1 and R2 are each independently hydrogen or C1-4 alkyl;
• R3 is C1-4 alkyl, C2-4 alkenyl or C2-4 alkynyl;
• Rf is hydrogen, C1-4 alkyl, C1-4 haloalkyl, cyano substituted C1-4 alkyl, C2-4 alkenyl, C2-4 alkynyl, C3-8 cycloalkyl, 4- to 8-membered heterocyclyl, aryl, heteroaryl, C(O)R4, C(O)OR1, C(O)NR1R2, S(O)2R4, or S(O)2NR1R2;
• each Rg is each independently selected from the group consisting of hydrogen, halogen, and C1-4 alkyl;
• or two Rg together with the carbon atom to which they are attached form a carbonyl group (C═O);
• or two Rg together with the carbon atom to which they attached form a 3- to 8-membered cyclic structure which optionally comprises 0, 1 or 2 heteroatoms selected from N, O or S;
• R4 is C1-4 alkyl, C2-4 alkenyl, C2-4 alkynyl, C3-8 cycloalkyl, 4- to 8-membered heterocyclic group, aryl, or heteroaryl;
• wherein each of the above alkyl, alkenyl, alkynyl, cycloalkyl, heterocyclyl, aryl and heteroaryl is optionally and independently substituted by 1 to 3 substituents which are each independently selected from the group consisting of halogen, C1-4 alkyl, C1-4 haloalkyl, C2-4 alkenyl, C2-4 alkynyl, C3-8 cycloalkyl, 3- to 8-membered heterocyclic group, aryl, heteroaryl, CN, NO2, OR1, SR1, NR1R2, C(O)R4, C(O)OR1, C(O)NR1R2, NR1C(O)R4, and S(O)2R4;
• the R1, R2 and R4 are defined as above;
• unless otherwise specified, the aryl is aromatic groups having 6 to 12 carbon atoms;
• the heteroaryl is 5- to 15-membered heteroaromatic groups;
• and the cyclic structure is saturated or unsaturated cyclic groups with or without heteroatoms.