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US 12,589,091 B2Granted
Topical formulation comprising sirolimus
AssigneeSodha Pharma Consulting GmbH
InventorSodha Ravindrakumar Jivan
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Abstract
The present invention concerns a pharmaceutical composition for topical administration, comprising sirolimus, solvent, thickener and glycol ether. The invention further concerns a pharmaceutical composition for use in the treatment of skin diseases or skin manifestations of diseases, especially of skin manifestations of tuberous sclerosis complex (TSC). The invention further concerns a method for producing a pharmaceutical composition comprising the steps of (i) providing sirolimus and (ii) forming the present composition.
Claims12
A pharmaceutical composition suitable for topical administration comprising:
- a) sirolimus,
- b) solvent,
- c) thickener and
- d) glycol ether
- wherein the content of sirolimus a) is between 0.05 and 5.0 wt. % based on the total weight of the composition,
- wherein the content of thickener c) is between 0.05 and 10.0 wt. % based on the total weight of the composition,
- wherein the content of glycol ether d) is between 0.05 and 10.0 wt. % based on the total weight of the composition,
- wherein solvent b) is selected from the group consisting of propylene glycol, glycerin, alcohol, water or a mixture thereof, and
- wherein thickener c) comprises acrylamide/sodium acryloyldimethyl taurate copolymer.
6 more elements
Dependencies are inferred from the claim text.