Back to results
US 12,589,080 B2Granted
Enhanced two-stage microparticle-based localized therapeutic delivery system
AssigneePrivo Technologies, Inc.
InventorsManijeh N. Goldberg, Aaron M. Manzi, Eric R. Goldberg
Life of this patent
Estimating the term…
Abstract
A system is disclosed for delivery of a therapeutic agent to a site in mucosal tissue or to the skin of a patient. The system includes a porous mucoadhesive, freeze-dried matrix formed by a composition including chitosan in an aqueous salt solution of a chloride salt of a monovalent cation. The system further includes a plurality of chitosan microparticles having an average diameter between 500 nm and 2000 nm and comprising a therapeutic agent.
Claims28
A system comprising:
- a polymeric matrix comprising:
- chitosan having a concentration of from about 20 to about 30% (w/w) of the polymeric matrix;
- a chloride salt of a monovalent cation having a concentration of from about 10 to about 18% (w/w) of the polymeric matrix;
- a hydration promoter having a concentration of from about 5 to about 25% (w/w) of the polymeric matrix:
- a particle adhesion inhibitor having a concentration of from about 0.1 to about 10% (w/w) of the polymeric matrix;
- a particle aggregation inhibitor in having a concentration of from about 0.1 to about 30% (w/w) of the polymeric matrix;
- and
- a plurality of microparticles each comprising a chitosan coating and a therapeutic agent;
- wherein the microparticles have an average diameter between 500 nm and 2000 nm and are present in an amount of from about 10 to about 40% (w/w) of the polymeric matrix.
6 more elements
Dependencies are inferred from the claim text.