Low-dosage orodispersible opioid tablet and method for preparing same

A low-dosage orodispersible opioid tablet comprising:

• 10 to 30% by weight, relative to the total weight of the tablet, of opioid granules, said granules having a particle size from 200 to 1,100 μm, said granules consisting of:
• 7 to 28% by weight, relative to the weight of the granules, of an opioid selected from morphine or morphine sulfate as an active ingredient, and
• 72% to 93% by weight, relative to the weight of the granules, of a mixture of diluent and binder, said diluent being selected from the group consisting of mannitol, microcrystalline cellulose, and mixtures thereof, and said binder being selected from the group consisting of hydroxypropylcellulose, hydroxypropylmethylcellulose, hydroxyethylcellulose and mixtures thereof, wherein a ratio between the diluent and the binder in said granules is from 20:1 to 10:1, and
• 70% to 90% by weight, relative to the total weight of the tablet, of a mixture of compression excipients consisting of at least one disintegrating agent, one diluting agent, one lubricating agent, one permeabilizing agent, and optionally a sweetener, a flavoring agent, and/or a coloring agent, wherein:
• a ratio between the lubricating agent and the permeabilizing agent being greater than 1,
• the lubricating agent is present in an amount from 1 to 2% by weight, relative to the total weight of the tablet, and
• the permeabilizing agent is present in an amount from 0.5 to less than 2% by weight, relative to the total weight of the tablet,
• wherein said opioid is the active ingredient of the low-dosage orodispersible opioid tablet.