Wearable device and method for non-invasive assessment of glymphatic flow

A method for measuring glymphatic flow using a brain monitoring system, the brain monitoring system comprising a microcontroller and a head-mounted device, the method comprising:

• providing the head-mounted device worn by a subject, the head-mounted device comprising:
• a plurality of left electrodes in communication with the microcontroller, and
• a plurality of right electrodes in communication with the microcontroller;
• generating, by the microcontroller, input alternating currents over a range of frequencies during multiple iterations;
• providing, to the subject during each iteration of the multiple iterations, the input alternating currents over the range of frequencies via an input electrode and a sink electrode that the microcontroller selects from the plurality of left and right electrodes;
• collecting, from the subject during the multiple iterations with a plurality of sense electrodes, voltage difference measurements in response to the input alternating currents, wherein the plurality of sense electrodes comprises the plurality of left and right electrodes remaining after the microcontroller selects the input and sink electrodes;
• filtering, by a measurement validation module, invalid voltage difference measurements;
• generating, by the measurement validation module from validated voltage difference measurements, a time-series of validated impedance spectra over the multiple iterations, wherein a change in the validated impedance spectra over the multiple iterations indicates a change in flow of cranial interstitial fluid;
• determining, by a cranial fluid dynamics module, a model fit of the time-series of validated impedance spectra,
• outputting, by the cranial fluid dynamics module, a glymphatic flow response during the multiple iterations based upon the model fit of the time-series of validated impedance spectra, and
• responsive to receiving the glymphatic flow response, performing by the microcontroller one or more of displaying the glymphatic flow response on a display and administering at least one therapeutic intervention.