Cardiac pulse wave retrieval from an electrical signal

A system, comprising:

• a measurement device comprising a patch unit configured to be attached to a torso of a subject, the patch unit comprising a first plurality of sensors and a second plurality of sensors, wherein the first plurality of sensors are adapted to measure an electrocardiographic, ECG, signal of the subject, and the second plurality of sensors are adapted to measure an electrical signal of the subject, wherein the ECG signal of the subject indicates two or more consecutive heartbeat response cycles, and wherein at least one of the first or second plurality of sensors comprises an electrode;
• and
• a processing unit configured to receive the ECG signal and the electrical signal, wherein the processing unit is further configured to:
• determine a collection of points of interest in the ECG signal, wherein the points of interest comprise:
• peaks, dips, or where a slope of the ECG signal reaches a predetermined threshold,
• determine a collection of specific points in the electrical signal based on the collection of points of interest in the ECG signal as a starting point, wherein the specific points in the electrical signal comprise:
• peaks, dips, local maxima, or local minima, and wherein the determined collection of specific points includes two or more specific points in the electrical signal for the heartbeat response cycles indicated in the ECG signal,
• determine a cleaned electrical signal based on the collection of specific points in the electrical signal,
• generate a pulse wave signal by subtracting the cleaned electrical signal from the electrical signal, and
• determine at least one cardiovascular parameter of the subject based on the generated pulse wave signal, wherein the at least one cardiovascular parameter comprises at least one of:
• pulse amplitude ratio, arterial blood pressure, pulse transit time, arterial stiffness, left ventricular end diastolic volume pressure, or pulmonary capillary wedge pressure,
• wherein the collection of specific points in the electrical signal are determined based on timestamps of the collection of points of interest in the ECG signal, and wherein at least one of the two or more specific points in the electrical signal for every heartbeat response cycle indicated in the ECG signal is associated with a timestamp offset in time relative to the timestamp of the corresponding point of interest in the ECG signal, the timestamp offset being a time difference between the corresponding point of interest in the ECG signal and the at least one specific point in the electrical signal.

A system, comprising

• an implantable measurement device comprising a first plurality of sensors and a second plurality of sensors, wherein the first plurality of sensors are adapted to measure an electrocardiographic, ECG, signal of a subject, and the second plurality of sensors are adapted to measure an electrical signal of the subject, wherein the ECG signal of the subject indicates two or more consecutive heartbeat response cycles, and wherein at least one of the first or second plurality of sensors comprises an electrode;
• and
• a processing unit configured to receive the ECG signal and the electrical signal, wherein the processing unit is further configured to:
• determine a collection of points of interest in the ECG signal, wherein the points of interest comprise:
• peaks, dips, or where a slope of the ECG signal reaches a predetermined threshold,
• determine a collection of specific points in the electrical signal based on the collection of points of interest in the ECG signal as a starting point, wherein the specific points in the electrical signal comprise:
• peaks, dips, local maxima, or local minima, and wherein the determined collection of specific points includes two or more specific points in the electrical signal for the heartbeat response cycles indicated in the ECG signal,
• determine a cleaned electrical signal based on the collection of specific points in the electrical signal,
• generate a pulse wave signal by subtracting the cleaned electrical signal from the electrical signal, and
• determine at least one cardiovascular parameter of the subject based on the generated pulse wave signal, wherein the at least one cardiovascular parameter comprises at least one of:
• pulse amplitude ratio, arterial blood pressure, pulse transit time, arterial stiffness, left ventricular end diastolic volume pressure, or pulmonary capillary wedge pressure,
• wherein the collection of specific points in the electrical signal are determined based on timestamps of the collection of points of interest in the ECG signal, and wherein at least one of the two or more specific points in the electrical signal for every heartbeat response cycle indicated in the ECG signal is associated with a timestamp offset in time relative to the timestamp of the corresponding point of interest in the ECG signal, the timestamp offset being a time difference between the corresponding point of interest in the ECG signal and the at least one specific point in the electrical signal.