US 12,586,190 B2 · System and method of classification of biological particles

Abstract

A method and system for classification of cells and particles in a biological sample using an automated image-based feature extraction and classification architecture. A method operates by applying a mask or series of masks to an image, extracting features from the unmasked portions of the image based on the content and location of colored pixels, selecting a subset of the extracted features, and mapping the subset of the extracted features into a classifier architecture. In a majority of cases, the first level model architecture provides an accurate identification of the cell or particle. In a minority of cases, the classification of the cell or particle requires a second level step requiring the use of numerical or categorical values from the first level in combination with a second level model.

Claims20

Dependent claims

A method of determining a classification of a particle in a biological sample comprising:

acquiring an image of the particle with a digital camera;
receiving the image of the particle at a processor system;
and
utilizing the processor system to execute computer executable code stored on a non-transitory computer readable medium, the computer executable code comprising instructions that, when executed on the processor system, cause the processor system to:
input a first set of features into a first classifier, the first classifier configured to provide a first label among a set of labels and a first probability value associated with the first label, and
input a second set of features into a second classifier if the first probability value is below a first threshold, the second classifier configured to provide a second label among the set of labels.

3 more elements

Dependencies are inferred from the claim text.

System and method of classification of biological particles

Life of this patent

System and method of classification of biological particles

Life of this patent

Abstract

Claims20