Devices and cartridges for extracting bio-sample regions and molecules of interest

A cartridge processing system for molecular tests that include extracting one or more biological materials from a tissue, comprising:

• a sealing device;
• one or more cartridges;
• and
• a carousel that contains the one or more cartridges and allows each cartridge to be delivered into the sealing device, wherein the sealing device applies vacuum suction to the cartridge placed in the sealing device, and each cartridge comprises:
• a base having a receptacle inside the base, wherein the base comprises a transparent window placed under the receptacle, and the receptacle contains a slide on which the tissue is disposed;
• a solid lid placed over the receptacle and entirely covering the receptacle;
• a film disposed between the lid and the tissue, wherein a portion of the film, which covers the tissue, entirely contacts an inner surface of the lid, and the film is suitable to extract the one or more biological materials from the tissue;
• and
• a gasket in the base to surround the slide, wherein the lid creates a sealed chamber around the gasket that encloses the slide, and vacuum suction is applied through a port of the base to press the film against the tissue on the slide.