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US 12,584,925 B2Granted
Method of treating large vessel occlusion stroke
AssigneePockit Diagnostics Limited
InventorsEdoardo Gaude, Gonzalo Ladreda Mochales, Marcos Ladreda Mochales
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Abstract
The invention relates to the diagnosis of stroke resulting from occlusion of one or more large vessels in the brain, and in particular to the diagnosis of stroke resulting from occlusion of one or more large vessels in the brain using one or more biomarkers.
Claims29
A method of treating large vessel occlusion (LVO) stroke comprising:
- (i) identifying an individual presenting with stroke symptoms;
- (ii) determining that the individual is experiencing LVO stroke comprising:
- (a) within 24 hours of step (i), obtaining a blood sample from the individual;
- (b) measuring the amount of stroke biomarkers in the blood sample, or in plasma or serum derived therefrom, consisting of
- (1) measuring the amount of D-dimer;
- and
- (2) measuring the amount of glial fibrillary acidic protein (GFAP);
- and
- (iii) providing LVO therapy to the individual having elevated levels of D-dimer and decreased levels of GFAP compared to levels of D-dimer and GFAP in one or more controls.
6 more elements
A method of treating large vessel occlusion (LVO) stroke comprising:
- (i) identifying an individual presenting with stroke symptoms;
- (ii) determining that the individual is experiencing LVO stroke comprising:
- (a) within 24 hours of step (i), obtaining a blood sample from the individual;
- (b) measuring the amount of stroke biomarkers in the blood sample, or in plasma or serum derived therefrom consisting of
- (1) measuring the amount of D-dimer;
- (2) measuring the amount of glial fibrillary acidic protein (GFAP);
- and
- (3) measuring one or more of (i) the amount of osteopontin (OPN) and (ii) the amount of osteoprotegerin (OPG);
- and
- (iii) providing LVO therapy to the individual having elevated levels of D-dimer, decreased levels of GFAP, and one or more of (1) elevated levels of OPN and (2) elevated levels of OPG, compared to levels of D-dimer, GFAP, and OPN and/or OPG in one or more controls.
7 more elements
A method of treating large vessel occlusion (LVO) stroke comprising:
- (i) determining that an individual presenting with stroke symptoms is experiencing LVO stroke comprising:
- measuring the amount of stroke biomarkers in a blood sample obtained from the individual within 24 hours of the onset of the stroke symptoms, or in plasma or serum derived therefrom, consisting of
- (1) measuring the amount of D-dimer;
- and
- (2) measuring the amount of glial fibrillary acidic protein (GFAP);
- and
- (ii) providing LVO therapy to the individual having elevated levels of D-dimer and decreased levels of GFAP compared to levels of D-dimer and GFAP in one or more controls.
4 more elements
A method of treating large vessel occlusion (LVO) stroke in an individual in need thereof, the method comprising:
- providing LVO therapy comprising mechanical thrombectomy to the individual in need thereof, wherein the individual in need thereof is presenting with stroke symptoms and has D-dimer levels of at least 0.5 μg/ml and GFAP levels of less than 265 pg/ml in a sample of blood, or in serum or plasma derived therefrom, obtained from the individual within 24 hours of onset of the stroke symptoms.
Dependencies are inferred from the claim text.