Continuous microwave drying for vaccines

A continuous microwave vacuum-drying (CMVD) integrated package assembly system, comprising:

• a lower half of an integrated container having a first chamber and a second chamber;
• an upper half of the integrated container;
• a vacuum chamber configured to maintain a low-pressure gradient between an interior of the vacuum chamber and an exterior of the vacuum chamber;
• a frozen-drug dispenser configured to deliver a frozen compound into the first chamber of the lower half of the integrated container;
• a microwave emitter configured to emit microwave radiation onto the frozen compound delivered into the first chamber of the lower half of the integrated container;
• a reconstitution solution dispenser configured to deliver a reconstitution solution into the second chamber of the lower half of the integrated container;
• a container sealer configured to seal the upper half of the integrated container to the lower half of the integrated container to form an integrated package;
• and
• a conveyor belt configured to transport the lower half of the integrated container to the frozen-drug dispenser, the microwave emitter, the reconstitution solution dispenser, and then the container sealer, in order.

A large-container continuous microwave vacuum-drying method, comprising:

• loading, into an integrated container, a plurality of lower halves of a plurality of integrated packages;
• moving, by a conveyor belt, the integrated container into a vacuum chamber;
• filing, by a frozen-drug dispenser, a first chamber of one of the plurality of lower halves of the plurality of integrated packages loaded into the integrated container with a frozen compound;
• exposing, by microwave emitters, the frozen compound of the first chamber of one of the plurality of lower halves of the plurality of integrated packages loaded into the integrated container to microwave radiation to lyophilize the frozen compound into a lyophilized compound;
• filing, by a reconstitution solution dispenser, a second chamber of one of the plurality of lower halves of the plurality of integrated packages loaded into the integrated container with a reconstitution solution;
• removing, by the conveyor belt, the integrated container out of the vacuum chamber;
• and
• sealing, by a container sealer, a plurality of upper halves of the integrated packages loaded into the integrated container onto the plurality of lower halves of the integrated packages loaded into the integrated container to create a plurality of prefilled integrated packages.