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US 12,584,178 B2Granted
Salivary biomarkers for the detection of epidermoid cancer of the head and neck
AssigneeBionou Research, S.L.
InventorVicente Manuel Navarro López
Life of this patent
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Abstract
Present invention relates to the in vitro use of the level or concentration in a salivary or breath sample of bacteria belonging to the Alloprevotella, Prevotella, Campylobacter, Rothia, Catonella, Porphyromona, Fretibacterium genus, or any combination thereof, for the diagnosis of carcinomas or epidermoid cancers, especially epidermoid cancer of the head and neck, in a patient, or to obtain useful data that allow such a diagnosis.
Claims9
A method for treating epidermoid cancer of the laryngeal location in a human male patient suspected of having epidermoid cancer of the laryngeal location, comprising:
- i) selecting the patient for treatment when microbiota in a salivary sample of the patient comprises a lower concentration of bacteria belonging to the Alloprevotella genus relative to a predetermined reference cut-off value;
- and
- administering to the—patient a treatment for epidermoid cancer of the laryngeal location, wherein the treatment is selected from the group consisting of a partial or radical surgery, a radiation therapy, a neoadjuvant or induction chemotherapy, a concomitant chemoradiotherapy, a molecular therapy, an immunotherapy and combinations thereof.
Dependencies are inferred from the claim text.