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US 12,584,177 B2Granted
Detecting endometrial cancer
AssigneesMayo Foundation for Medical Education and Research, Exact Sciences Corporation
InventorsWilliam R. Taylor, John B. Kisiel, Douglas W. Mahoney, David A. Ahlquist, Hatim T. Allawi, Maria Giakoumopoulos
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Abstract
Provided herein is technology for endometrial cancer (EC) screening and particularly, but not exclusively, to methods, compositions, and related uses for detecting the presence of endometrial cancer and various subtypes of endometrial cancer.
Claims29
A method, comprising:
- treating DNA in a sample from a subject having or suspected of having endometrial cancer or a subtype of endometrial cancer with a reagent that modifies DNA in a methylation-specific manner;
- amplifying the treated DNA using a set of primers for one or more genes;
- and
- determining the methylation level of the one or more genes using polymerase chain reaction, nucleic acid sequencing, mass spectrometry, a methylation-specific nuclease, mass-based separation, and/or target capture;
- wherein the one or more genes is selected from GYPC, MAX.chr10.22624479-22624553, MAX.chr19.37288607-37288752, JSRP1, SPDYA, ZNF506 and SFMBT2.
2 more elements
Dependencies are inferred from the claim text.