Chromosome biomarker

A process for detecting a chromosome state in a human individual comprising determining whether a chromosome interactions relating to that chromosome state is present or absent in the individual, wherein said chromosome interactions relates to endurance or strength in an individual;

• wherein the process comprises detecting the presence or absence of:
• at least 10 of the 77 chromosome interactions shown in Table 25 which are present in the genes shown in Table 25.h, wherein each chromosome interaction is detected by a method comprising the steps of:
• (i) cross-linking of chromosome regions of the individual, wherein the chromosome regions have come together in a chromosome interaction,
• (ii) subjecting the cross-linked regions to cleavage;
• (iii) ligating the cross-linked cleaved DNA ends to form ligated nucleic acids, and
• (iv) detecting the presence or absence of a ligated nucleic acid corresponding to each chromosome interaction by a probe that has at least 70% identity to any of the specific probe sequences set forth in SEQ ID NOS:
• 128 to 204.