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US 12,584,145 B2Granted
Conjugate systems and methods of use thereof
AssigneeWashington University
InventorsDavid Curiel, Zhi Hong Lu
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Abstract
Among the various aspects of the present disclosure is the provision of conjugate systems and methods of use thereof. In an aspect, the conjugate system includes an adenovirus comprising an exterior surface, and at least one polypeptide comprising a first domain and a second domain, and wherein the exterior surface comprises a peptide tag capable of binding to a binding partner.
Claims25
A conjugate system comprising:
- (i) an adenovirus comprising an exterior surface, wherein the exterior surface comprises a hexon protein surface and a fiber knob surface;
- and
- (ii) at least one polypeptide comprising a first domain and a second domain, wherein the first domain comprises a binding partner and the second domain comprises a Cas protein;
- and
- wherein the hexon protein surface and/or the fiber knob surface comprises a peptide tag capable of binding to the binding partner.
2 more elements
A conjugate system comprising:
- (i) an adenovirus comprising an exterior surface comprising a hexon protein surface and a protein IX surfacer, and
- (ii) at least one polypeptide comprising a first domain and a second domain, wherein the first domain comprises a binding partner and the second domain comprises an mRNA-binding domain;
- and
- wherein the hexon protein surface and/or the protein IX surface comprises a peptide tag capable of binding to the binding partner.
1 more element
Dependencies are inferred from the claim text.