Aptamers for personal health care applications

Personal health care composition comprising an aptamer composition comprising at least one oligonucleotide consisting of:

• deoxyribonucleotides, ribonucleotides, derivatives of deoxyribonucleotides, derivatives of ribonucleotides, or mixtures thereof, wherein the aptamer composition has a binding affinity for intercellular adhesion molecule 1 (ICAM-1) and wherein the aptamer is configured to reduce the binding of one or more human rhinoviruses to the intercellular adhesion molecule 1 (ICAM-1), and wherein the aptamer composition comprises at least one oligonucleotide comprising from about 30 to about 60 nucleotides truncated from parent oligonucleotides, wherein the at least one oligonucleotide is
• a) an oligonucleotide with at least 90% nucleotide sequence identity to sequences selected from the group consisting of SEQ ID NO:
• 1 to SEQ ID NO:
• 200, and/or
• b) an oligonucleotide with at least 80% nucleotide sequence identity to sequences selected from the group consisting of SEQ ID NO:
• 1 to SEQ ID NO:
• 200, wherein the truncated aptamer comprises a GAGGYYZ motif, wherein Y is absent or A, and wherein Z is absent or G, C, A, T or U.

Method of inhibiting human rhinovirus infection by inhibiting binding of the human rhinovirus to the intercellular adhesion molecule 1 (ICAM-1) of epithelial cells comprising applying an aptamer composition comprising at least one oligonucleotide consisting of:

• deoxyribonucleotides, ribonucleotides, derivatives of deoxyribonucleotides, derivatives of ribonucleotides, and mixtures thereof,
• wherein the aptamer composition has a binding affinity for intercellular adhesion molecule 1 (ICAM-1) and wherein the aptamer is configured to reduce the binding of one or more human rhinoviruses to the intercellular adhesion molecule 1 (ICAM-1), and
• wherein the aptamer composition comprises at least one oligonucleotide comprising from about 30 to about 60 nucleotides truncated from parent oligonucleotides, wherein the at least one oligonucleotide is
• a) an oligonucleotide with at least 90% nucleotide sequence identity to sequences selected from the group consisting of SEQ ID NO:
• 1 to SEQ ID NO:
• 200, and/or
• b) an oligonucleotide with at least 80% nucleotide sequence identity to sequences selected from the group consisting of SEQ ID NO:
• 1 to SEQ ID NO:
• 200, wherein the truncated aptamer comprises a GAGGYYZ motif, wherein Y is absent or A, and wherein Z is absent or G, C, A, T or U.