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US 12,584,127 B2Granted
Exosomes and micro-ribonucleic acids for tissue regeneration
AssigneeCedars-Sinai Medical Center
InventorsEduardo Marbán, Ke Cheng, Ahmed Ibrahim
Life of this patent
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Abstract
Several embodiments relate to methods of repairing and/or regenerating damaged or diseased tissue comprising administering to the damaged or diseased tissues compositions comprising exosomes. In several embodiments, the exosomes comprise one or more microRNA that result in alterations in gene or protein expression, which in turn result in improved cell or tissue viability and/or function.
Claims21
A method of treating a subject having damaged cardiac tissue, comprising:
- administering a preparation of exosomes harvested from cardiospheres or cardiosphere-derived cells (CDCs) to the subject;
- wherein administration of the preparation of exosomes improves the function of said damaged cardiac tissue.
A method of treating a subject having damaged cardiac tissue, comprising:
- administering a preparation of exosomes harvested from cardiosphere-derived cells (CDCs) to the subject;
- wherein administration of the preparation of exosomes improves the function of said damaged cardiac tissue;
- wherein the damaged cardiac tissue is a result of chronic disease.
Dependencies are inferred from the claim text.