Compositions and methods for delivery of immune cells to treat un-resectable or non-resected tumor cells and tumor relapse
AssigneeFred Hutchinson Cancer Center
InventorMatthias Stephan
Life of this patent
Estimating the term…
Abstract
The present disclosure provides compositions and methods for the delivery of immune cells to treat un-resectable or non-resected tumor cells and tumor relapse. The compositions comprise (i) a structure comprising an injectable polymer or scaffold comprising pores; (ii) lymphocytes disposed within the structure, (iii) at least one lymphocyte-adhesion moiety associated with the structure; and (iv) at least one lymphocyte-activating moiety associated with the structure, and optionally an immune stimulant.
Claims21
A method comprising adding tumor reactive lymphocytes into a porous scaffold comprising at least one antibody selected from an anti-CD3 antibody, an anti-CD28 antibody, an anti-CD137 antibody, an anti-CD27 antibody, an anti-CD80 antibody, an anti-CD86 antibody, an anti-OX40 antibody, an anti-CD40 antibody, an anti-CD7 antibody, and an anti-B7-H3 antibody.
A method comprising
- genetically modifying lymphocytes;
- and
- adding genetically modified lymphocytes into a porous scaffold comprising at least one antibody selected from an anti-CD3 antibody, an anti-CD28 antibody, and an anti-CD137 antibody.
A method of forming a porous scaffold comprising
- obtaining collagen or alginate;
- obtaining at least one antibody selected from an anti-CD3 antibody, an anti-CD28 antibody, and an anti-CD137 antibody;
- and
- adding the collagen or alginate and at least one antibody into a solution that results in formation of a three-dimensional gel comprising the collagen or alginate and the at least one antibody;
- thereby forming the porous scaffold.
Dependencies are inferred from the claim text.