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US 12,584,105 B2Granted
Autologous cell replacement therapy for Parkinson's disease
AssigneeThe McLean Hospital Corporation
InventorKwang-Soo Kim
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Abstract
Methods for generating midbrain dopamine (mDA) neuronal progenitor cells useful for autologous cell therapy in Parkinson's Disease, compositions comprising the cells, and methods of use thereof.
Claims20
A method of generating a population of midbrain dopaminergic progenitor cells (mDAPs), the method comprising:
- providing a population of induced pluripotent stem cells (iPSCs);
- plating the population of cells in discrete, individual areas with sufficient distance between the areas to maintain isolation between the areas, in a biomatrix hydrogel support, with a density of about 5,000-20,000, preferably about 10,000, cells per area;
- and
- maintaining the cells in the isolated areas under conditions sufficient for the iPSCs to differentiate into mDAPs.
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Dependencies are inferred from the claim text.