Synthesis of uniformly defined molecular weight mannosylated dextrans and derivatives thereof
AssigneeNavidea Biopharmaceuticals, Inc.
InventorsJeffrey Arnold, David A. Ralph
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Abstract
Disclosed herein is method for conjugating a metal chelating agent to a functionalized dextran by reacting a chelator with an aminated dextran backbone, where the chelator comprises a one, and only one, derivatized carboxylic acid group to form a chelator-dextran complex. In certain aspects, the dextran-chelator complex is substantially free of intra- or intermolecular crosslinking. In certain aspects, the functionalized dextran is an amine dextran, an alkynyl dextran, or a thiol dextran. In exemplary implementations, the functionalized dextran is an amine dextran. In further embodiments, one and only one carboxylic acid group on the chelating agent is derivatized as a N-hydroxysuccinimide (NHS) ester.
Claims8
A substantially pure compound comprising:
- a carbohydrate backbone to which amine terminated leashes have been appended and one or more chelator moieties attached thereto without crosslinking, wherein the chelator is 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid (DOTA) or diethylenetriaminepentaacetic acid (DTPA).
Dependencies are inferred from the claim text.