US 12,583,935 B2 · Anti-human CD47 antibody and antigen-binding fragment thereof, and preparation method therefor and use thereof

Abstract

Provided in the present invention are an anti-human CD47 antibody or an antigen-binding fragment thereof, and a preparation method therefor and the use thereof. Also provided in the present invention are an isolated polynucleotide encoding the antibody or the antigen-binding fragment thereof and a vector containing the isolated polynucleotide of the present invention. Further provided in the present invention is the use of the antibody or the antigen-binding fragment thereof according to the present invention in the preparation of a drug, the drug being used for treating and/or preventing a disease that benefits from an enhanced immune response, wherein the disease is cancer.

Claims19

Dependent claims

An anti-human CD47 antibody or an antigen-binding fragment thereof comprising the following heavy chain complementarity determining regions:

a VH CDR1 comprising an amino acid sequence set forth in SEQ ID NO:
1;
a VH CDR2 comprising an amino acid sequence set forth in SEQ ID NO:
2;
and
a VH CDR3 comprising an amino acid sequence set forth in SEQ ID NO:
3;
and the following light chain complementarity determining regions:
a VL CDR1 comprising an amino acid sequence set forth in SEQ ID NO:
4;
a VL CDR2 comprising an amino acid sequence set forth in SEQ ID NO:
5;
and
a VL CDR3 comprising an amino acid sequence set forth in SEQ ID NO:
6.

12 more elements

Dependencies are inferred from the claim text.

Facts

Application

17/995,190Filed 31 Mar 2021

Priority

CN 202010240238.731 Mar 2020

Published

US 2023/0167192 A11 Jun 2023

Granted

24 Mar 2026

Term ends

Not estimatedThe source records don’t support an estimate.

Classification15 codes

C07K 16/2896
Against receptors, cell surface antigens or cell surface determinants: against molecules with a "CD"-designation, not provided for elsewhere
A61P 35/00
Antineoplastic agents
C07K 16/2803
Against receptors, cell surface antigens or cell surface determinants: against the immunoglobulin superfamily
C12N 15/63
Recombinant DNA-technology: introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression

Anti-human CD47 antibody and antigen-binding fragment thereof, and preparation method therefor and use thereof

Life of this patent

Anti-human CD47 antibody and antigen-binding fragment thereof, and preparation method therefor and use thereof

Life of this patent

Abstract

Claims19