CD38 and ICAM1 antibodies and uses thereof
AssigneesVirtuoso BINco, Inc., The Regents of the University of California
InventorsBin Liu, Xiaocheng Chen, Scott Bidlingmaier, Leonard Post, Yang Su, Namkyung Lee
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Abstract
Disclosed herein are anti-CD38 antibodies, anti-ICAM1 antibodies, pharmaceutical compositions comprising anti-CD38 antibodies and/or anti-ICAM1 antibodies, and methods of use for the treatment of a proliferative disease. In certain embodiments, also disclosed herein are multi-specific antibodies (e.g., bispecific antibodies) comprising a first targeting moiety that specifically binds to CD38 and a second targeting moiety that specifically binds to ICAM1, pharmaceutical compositions comprising the multi-specific antibodies, and methods of use for the treatment of a proliferative disease.
Claims23
A multispecific protein comprising (i) a first component comprising an antibody or an antigen binding fragment thereof that specifically binds to CD38 and (ii) a second component comprising an antibody or an antigen binding fragment thereof that specifically binds to ICAM1, wherein:
- (a) the first component that specifically binds to CD38 comprises:
- (i) a heavy chain variable domain (VH) comprising complementarity determining regions HCDR1, HCDR2, and HCDR3 comprising the sequences of SEQ ID NO:
- 1, 2, and 7, respectively, and
- (ii) a light chain variable domain (VL) comprising complementarity determining regions LCDR1, LCDR2, and LCDR3 comprising the sequences of SEQ ID NO:
- 62, 63, and 64, respectively;
- and
- (b) the second component that specifically binds to ICAM1 comprises:
- (i) a heavy chain variable domain (VH) comprising complementarity determining regions HCDR1, HCDR2, and HCDR3 comprising the sequences of 228, 229, and 230, respectively, and
- (ii) a light chain variable domain (VL) comprising complementarity determining regions LCDR1, LCDR2, and LCDR3 comprising the sequences of SEQ ID NO:
- 270, 260, and 271, respectively.
Dependencies are inferred from the claim text.