Antibody and chimeric antigen receptor (CAR) binding to CD70, and application thereof

A CD70-targeting fully human antibody or a single-chain antibody or an antigen-binding fragment thereof, wherein the fully human antibody comprises a heavy chain variable region (HC VR) and/or a light chain variable region (LCVR), and the heavy chain variable region comprises a HCDR1, a HCDR2 and a HCDR3, the light chain variable region comprises a LCDR1, a LCDR2 and a LCDR3, and the HCDR1, HCDR2, HCDR3 and/or LCDR1, LCDR2 and LCDR3 are any one selected from:

• (1) the LCDR1 having an amino acid sequence of SSNIGRNT (SEQ ID NO:
• 75);
• the LCDR2 having an amino acit sequence of SND (SEQ ID NO:
• 76);
• the LCDR3 having an amino acid sequence of ASWDDSLTGWYV (SEQ ID NO:
• 77);
• the HCDR1 having an amino acid sequence of GGSFTNYL (SEQ ID NO:
• 72);
• the HCDR2 having an amino acid sequence of IIPVYGTP (SEQ ID NO:
• 73);
• and the HCDR3 having an amino acid sequence of VREDEGYGDLYLAY (SEQ ID NO:
• 74);
• (2) the HCDR1 having an amino acid sequence of GFTFNIDA (SEQ ID NO:
• 78);
• the HCDR2 having an amino acid sequence of ISSSGGTT (SEQ ID NO:
• 79);
• and the HCDR3 having an amino acid sequence of ARSRYSVPDGRGSYDV (SEQ ID NO:
• 80);
• (3) the HCDR1 having an amino acid sequence of GFTFSSEA (SEQ ID NO:
• 80);
• the HCDR2 having an amino acid sequence of INASGRNT (SEQ ID NO:
• 82);
• the HCDR3 having an amino acid sequence of ARKHGEY YDSGYDV (SEQ ID NO:
• 83);
• (4) the HCDR1 having an amino acid sequence of GFTFSSYA (SEQ ID NO:
• 84);
• the HCDR2 having an amino acid sequence of ISGYGEET (SEQ ID NO:
• 85);
• and the HCDR3 having an amino acid sequence of ARFYYRYWKEFDY (SEQ ID NO:
• 86);
• and
• (5) the HCDR1 having an amino acid sequence of GFTFSNYA (SEQ ID NO:
• 87);
• the HCDR2 having an amino acid sequence of ITGLGGNM (SEQ ID NO:
• 88);
• and the LCDR3 having an amino acid sequence of ARMYYSQGVNNYSYPSTDI (SEQ ID NO:
• 89).