Method of treating acute respiratory distress syndrome

A method for reducing lung inflammation in a subject suffering from acute respiratory distress syndrome (ARDS) or at risk of developing ARDS, the method comprising administering a compound that inhibits granulocyte colony stimulating factor (G-CSF) signaling to the subject, wherein the compound that inhibits G-CSF signaling is a protein comprising an antigen binding site that specifically binds to G-CSF receptor (G-CSFR) and neutralizes G-CSF signaling, wherein the protein:

• a) comprises an antibody variable region comprising a heavy chain variable region (VH) comprising an amino acid sequence set forth in SEQ ID NO:
• 4 and a light chain variable region (VL) comprising an amino acid sequence set forth in SEQ ID NO:
• 5;
• and/or
• b) comprises an antibody variable region comprising a VH comprising an amino acid sequence set forth in SEQ ID NO:
• 2 and a VL comprising an amino acid sequence set forth in SEQ ID NO:
• 3;
• and/or
• c) comprises an antibody variable region comprising a VH comprising three complementarity determining regions (CDRs) of a VH comprising an amino acid sequence set forth in SEQ ID NO:
• 4 and a VL comprising three CDRs of a VL comprising an amino acid sequence set forth in SEQ ID NO:
• 5, wherein the CDRs are defined according to the numbering system of Kabat.