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US 12,583,928 B2Granted
Antibodies against IGFR-like receptor and uses thereof
AssigneeHelmholtz Zentrum München Deutsches Forschungszentrum für Gesundheit und Umwelt (GmbH)
InventorHeiko Lickert
Life of this patent
Estimating the term…
Abstract
The present invention provides a novel IGFR-like receptor and antagonists and agonists for targeting said receptor. Said antagonists and agonists are envisaged for use as a medicament, and in particular for treatment of diabetes.
Claims15
An antibody or a fragment thereof which specifically binds to an IGFR-like receptor epitope, wherein said antibody or fragment thereof comprises complimentary determining regions (CDRs):
- CDR-H1:
- (SEQ ID NO:
- 13 or 19)
- SYHIS,
- CDR-H2:
- (SEQ ID NO:
- 14 or 20)
- AISSGGDTYYNSLLKS,
- CDR-H3:
- (SEQ ID NO:
- 15 or 21)
- ESY,
- CDR-L1:
- (SEQ ID NO:16 or 22)
- RASENIDTYLH,
- CDR-L2:
- (SEQ ID NO:
- 17 or 23)
- FASQSIS, and
- CDR-L3:
- (SEQ ID NO:
- 18 or 24)
- QQGNILPYT;
- or
- CDR-H1:
- (SEQ ID NO:
- 25)
- SYWMD,
- CDR-H2:
- (SEQ ID NO:
- 26)
- NIYPSDGETHYNQKFKD,
- CDR-H3:
- (SEQ ID NO:
- 27)
- LYSEYGS,
- CDR-L1:
- (SEQ ID NO:
- 28)
- KSSQSLLNSGNQKNYLT,
- CDR-L2:
- (SEQ ID NO:
- 29)
- WASTRDS, and
- CDR-L3:
- (SEQ ID NO:
- 30)
- QNDYSYPLT.
45 more elements
Dependencies are inferred from the claim text.