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US 12,583,926 B2Granted
CD47/pd-L1-targeting protein complex and methods of use thereof
AssigneeFBD Biologics Limited
InventorsJiin-Tarng Wang, Han-Fang Teng, Yun-Chih Cheng, Pan-Hsien Kuo, Chieh-Hsin Ho, Wei-Tse Sun, Chia-Zhen Wu, Tsai-Kuei Shen, Chi-Ling Tseng, Zong Sean Juo
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Abstract
This disclosure relates to protein complexes targeting CD47, PD-L1, and/or TGFβ, and methods of use thereof. In one aspect, the protein complexes include a CD47-binding domain having all or a portion of the SIRPα extracellular region; a PD-L1-binding domains having a VHH that binds to PD-L1; and optionally a TGFβ-binding domain having all or a portion of the TGFBRII extracellular region.
Claims13
A protein complex, comprising
- (a) a first polypeptide comprising from N-terminus to C-terminus:
- a first CD47-binding domain, a first VHH that binds to PD-L1, a first Fc region, and a first TGFβ-binding domain;
- and
- (b) a second polypeptide comprising from N-terminus to C-terminus:
- a second CD47-binding domain, a second VHH that binds to PD-L1, a second Fc region, and a second TGFβ-binding domain,
- wherein the first VHH and the second VHH comprise a sequence that is identical to SEQ ID NO:
- 8;
- wherein the first CD47-binding domain and the second CD47-binding domain comprise a sequence that is identical to SEQ ID NO:
- 7;
- wherein the first TGFβ-binding domain and the second TGFβ-binding domain comprise a sequence that is identical to SEQ ID NO:
- 9.
8 more elements
Dependencies are inferred from the claim text.