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AssigneeLay Sciences, Inc.
InventorUday Saxena
Estimating the term…
Provided are methods for treating a disorder characterized by elevated blood glucose levels in a subject in need thereof, comprising administering to the subject a therapeutically effective amount of a hyperimmunized egg product obtained from an egg-producing animal, wherein the hyperimmunized egg product comprises a therapeutically effective amount of one or more IgY antibodies to an extracellular glucose binding domain of a sodium-glucose co-transporter SGLT. Also provided are hyperimmunized eggs and egg products produced by an animal that has been hyperimmunized with an antigen that contains an extracellular glucose binding domain of a sodium-glucose co-transporter SGLT or fraction thereof, and use of the hyperimmunized eggs or hyperimmunized egg products to reduce blood glucose levels in a subject, such as to treat type 2 diabetes. Methods or preparing the hyperimmunized eggs and hyperimmunized egg products are also provided.
An antibody characterized in that it binds to an extracellular glucose binding domain of a sodium—glucose co-transporter SGLT comprising a sequence selected from among:
A hyperimmunized egg produced by an avian that has been hyperimmunized with an antigen that comprises an extracellular glucose binding domain of a sodium—glucose co-transporter SGLT, wherein a level of antibodies to the antigen in the hyperimmunized egg is increased relative to an egg from an animal that has not been hyperimmunized, wherein the antigen comprises a sequence selected from among:
A formulation, comprising:
Dependencies are inferred from the claim text.