Antibodies that bind to LRP6 proteins and methods of use

An antibody that specifically binds LRP6, comprising a light chain variable region and a heavy chain variable region, the heavy chain variable region comprising complementarity determining regions CDR-H1, CDR-H2 and CDR-H3, the light chain variable region comprising complementarity determining region CDR-L1, CDR-L2 and CDR-L3, wherein the amino acid sequences of said CDR sequences are a full CDR sequence set selected from the following sets of CDR sequences:

• a) CDR-H1 of SEQ ID NO:02, CDR-H2 of SEQ ID NO:06, CDR-H3 of SEQ ID NO:10 and CDR-L1 of SEQ ID NO:14, CDR-L2 of SEQ ID NO:15 and CDR-L3 of SEQ ID NO:20;
• b) CDR-H1 of SEQ ID NO:25, CDR-H2 of SEQ ID NO:07, CDR-H3 of SEQ ID NO:11 and CDR-L1 of SEQ ID NO:14, CDR-L2 of SEQ ID NO:15 and CDR-L3 of SEQ ID NO:17;
• c) CDR-H1 of SEQ ID NO:25, CDR-H2 of SEQ ID NO:08, CDR-H3 of SEQ ID NO:12 and CDR-L1 of SEQ ID NO:14, CDR-L2 of SEQ ID NO:15 and CDR-L3 of SEQ ID NO:18;
• d) CDR-H1 of SEQ ID NO:04, CDR-H2 of SEQ ID NO:09, CDR-H3 of SEQ ID NO:13 and CDR-L1 of SEQ ID NO:14, CDR-L2 of SEQ ID NO:15 and CDR-L3 of SEQ ID NO:19;
• e) CDR-H1 of SEQ ID NO:05, CDR-H2 of SEQ ID NO:06, CDR-H3 of SEQ ID NO:10 and CDR-L1 of SEQ ID NO:14, CDR-L2 of SEQ ID NO:15 and CDR-L3 of SEQ ID NO:20;
• and
• f) CDR-H1 of SEQ ID NO:26, CDR-H2 of SEQ ID NO:27, CDR-H3 of SEQ ID NO:
• 10 and CDR-L1 of SEQ ID NO:14, CDR-L2 of SEQ ID NO:15 and CDR-L3 of SEQ ID NO:20.