Methods to improve glucose tolerance in a subject by administering an antibody that binds to extracellular human metallothionein 1A (MT1A)
AssigneesUniversity of Connecticut, Joslin Diabetes Center, Inc.
InventorsMichael A. Lynes, Yu-Hua Tseng, Matthew D. Lynes
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Abstract
Provided are methods for use of an antibody, such as a monoclonal antibody and/or a humanized antibody, that binds to extracellular human metallothionein 1A (MT1A), or an antigenic binding fragment thereof, to improve glucose tolerance in a subject.
Claims12
A method for improving glucose tolerance in a subject in need thereof, comprising administering to the subject a therapeutically effective amount of a composition comprising an inhibitor of extracellular human metallothionein 1A (MT1A) to treat or limit development of the disorder, wherein the inhibitor of extracellular human MT1A comprises an anti-MT1A antibody or an antigen-binding fragment thereof.
Dependencies are inferred from the claim text.