Flavivirus cross neutralizing antibody and pharmaceutical composition
AssigneeJapan Institute for Health Security
InventorsYoshimasa Takahashi, Arnone Nithichanon, Takayuki Matsumura, Ryosuke Suzuki, Chang-Kweng Lim, Ganjana Lertmemongkolchai
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Abstract
Provided is a flavivirus cross neutralizing antibody which has an excellent ability to control infection with suppressed ADE. This is a flavivirus cross neutralizing antibody that specifically binds to domains of E protein of flavivirus and thereby has an ability to control infection with at least two viruses included in the flavivirus. The domains of E protein include a plurality of domains including domain III. The flavivirus includes, for example, Zika virus, dengue virus types 1-4, and Japanese encephalitis virus.
Claims6
A flavivirus cross neutralizing antibody that specifically binds to E protein of flavivirus,
- wherein the flavivirus cross neutralizing antibody comprises:
- a heavy chain variable region comprising complementarity determining region 1 (CDR1) of GFTFSRTT (SEQ ID NO:
- 3), CDR2 of IVIGTGST (SEQ ID NO:
- 4), and CDR3 of ATNPTTVFGVVTPDYYYYPMEV (SEQ ID NO:
- 5), and
- a light chain variable region comprising CDR1 of NSNIGSNF (SEQ ID NO:
- 10), CDR2 of RND, and CDR3 of AVWDDTLRVWV (SEQ ID NO:
- 11).
Dependencies are inferred from the claim text.