Polypeptides for restoring endothelial function and methods of use thereof

A method for restoring endothelial function, comprising:

• administering to a subject in need thereof an effective amount of a polypeptide comprising:
• an amino acid sequence according to the general formula X1-X2;
• wherein
• X1 comprises a transduction domain, wherein the transduction domain comprises GRKKRRORRRPPQ (SEQ ID NO:3);
• AYARAAARQARA (SEQ ID NO:4);
• DAATATRGRSAASRPTERPRAPARSASRPRRPVE (SEQ ID NO:5);
• GWTLNSAGYLLGLINLKALAALAKKIL (SEQ ID NO:6);
• PLSSISRIGDP (SEQ ID NO:7);
• AAVALLPAVLLALLAP (SEQ ID NO:8);
• AAVLLPVLLAAP (SEQ ID NO:9);
• VTVLALGALAGVGVG (SEQ ID NO:10);
• GALFLGWLGAAGSTMGAWSQP (SEQ ID NO:11);
• GWTLNSAGYLLGLINLKALAALAKKIL (SEQ ID NO:12);
• KLALKLALKALKAALKLA (SEQ ID NO:13);
• KETWWETWWTEWSQPKKKRKV (SEQ ID NO:14);
• KAFAKLAARLYRKAGC (SEQ ID NO:15);
• KAFAKLAARLYRAAGC (SEQ ID NO:16);
• AAFAKLAARLYRKAGC (SEQ ID NO:17);
• KAFAALAARLYRKAGC (SEQ ID NO:18);
• KAFAKLAAQLYRKAGC (SEQ ID NO:19), AGGGGYGRKKRRORRR (SEQ ID NO:20);
• YGRKKRRORRR (SEQ ID NO:21);
• YARAAARQARA (SEQ ID NO:22);
• or LTVK (SEQ ID NO:23);
• and
• X2 comprises a polypeptide capable of restoring endothelial function;
• wherein X2 is selected from SPAARRA (pS) AILPG (SEQ ID NO:24);
• SPARRA (pS) AILPG (SEQ ID NO:25);
• SPAARRV (pS) AILPG (SEQ ID NO:26);
• SPARRV (pS) AILPG (SEQ ID NO:27);
• SPAARGA (pS) AILPG (SEQ ID NO:28);
• SPARGA (pS) AILPG (SEQ ID NO:29);
• ARRA (pS) AILPG (SEQ ID NO:30);
• ARRV (pS) AILPG (SEQ ID NO:31);
• ARGA (pS) AILPG (SEQ ID NO:32);
• or SPARRA (pS) ALLPG (SEQ ID NO:74);
• wherein X2 includes Z3;
• and
• wherein Z3 is selected from a phosphoserine or a phosphoserine analog.